印晓星

个人简历

1988年毕业于中国药科大学药学专业，1998~1999年香港大学医学院访问学者，2004年毕业于南京医科大学，获药理学专业博士学位。江苏省“333高层次人才培养工程”第二层次培养对象，江苏省高校优秀科技创新团队带头人。现任中国药理学会麻醉药理学分会副主任委员、江苏省药理学会副理事长、江苏省药理学会新药临床前药理专业委员会主任委员、教育部高等学校药学类专业教学指导委员会委员、江苏省理学2类研究生教育指导委员会主任委员等。长期从事糖尿病并发症的发病机制及其防治药物的研究工作。主持国家自然科学基金2项，江苏省自然科学基金1项，江苏省333工程资助项目1项，江苏省高校自然科学研究项目重大项目1项等。近几年在国内外重要学术刊物上以通讯作者或第一作者发表糖尿病肾病领域系列论文80余篇，其中SCI收录论文60余篇。2004年获得中国药理学会第八届Servier青年药理学工作者奖，2007年获徐州市科技进步一等奖1项（排名第一），2008年获淮海科技进步一等奖1项（排名第一），2015年徐州市科技进步一等奖1项（排名第一），以第一完成人申请专利8项，授权5项。

承担科研课题

1.    国家自然科学基金，81973377，Lnc-KIFAP3-5:1通过Prrx1b调控糖尿病肾病肾小管上皮间质转分化的分子机制，2020.01~2023.12，55万元，主持。

2.    国家自然科学基金，81473257，mTOR/YY1/p53通路在糖尿病肾病肾小管上皮细胞转分化中的作用及槲皮素的干预效应，2015.01~2018.12，80万元，主持。

3.    江苏省自然科学基金，BK20151155，基于mTOR/YY1信号通路的槲皮素及其衍生物防治糖尿病肾脏纤维化的作用研究，2015.07~2018.07，10万元，主持。

4.    江苏省高校自然科学基金重大项目，15KJA310005，Sirt1介导的YY1去乙酰化在糖尿病肾病中的作用，2015.07~2018.06，30万元，主持。

近三年代表性论文

1.    Du L, Li CC, Qian X, Chen YB, Wang L, Yang H, Li XZ, Li Y, Yin XX*, Lu Q*. Quercetin inhibited mesangial cell proliferation of early diabetic nephropathy through the Hippo pathway. Pharmacol Res. 2019; 146:104320.

2.    Yang T, Shu F, Yang H, Heng C, Zhou Y, Chen Y, Qian X, Du L, Zhu X, Lu Q*, Yin X*. YY1: A novel therapeutic target for diabetic nephropathy orchestrated renal fibrosis. Metabolism. 2019; 96:33-45.

3.    Xia Zhu, Wenhua Li, Yongkun Li, Wenhua Xu, Yirong Yuan, Victor Zheng, Hanting Zhang, James M O'Donnell, Ying Xu*, Xiaoxing Yin*. The Antidepressant- And Anxiolytic-Like Effects of Resveratrol: Involvement of phosphodiesterase-4D Inhibition. Neuropharmacology. 2019 Jul 15; 153:20-31.

4.    Yanyan Yu, Tianxiao Yin, Qiwen Peng, Lingna Kong, Chenglin Li, Daoquan Tang*, Xiaoxing Yin*. Simultaneous Monitoring of Amyloid-β (Aβ) Oligomers and Fibrils for Effectively Evaluating the Dynamic Process of Aβ Aggregation. ACS Sens. 2019 Feb 22;4(2):471-478.

5.    Deng-Pan Wu, Li-Ru Bai, Yan-Fang Lv, Yan Zhou, Chun-Hui Ding, Si-Man Yang, Fan Zhang, Yuan-Yuan Wang, Jin-Lan Huang, Xiao-Xing Yin*. A Novel Role of Connexin 40-Formed Channels in the Enhanced Efficacy of Photodynamic Therapy. Front Oncol. 2019 Jul 9; 9:595.

6.    Hu Wang, Rumeng Zhang, Yangyang Zhu, Tian Teng, Yujia Cheng, Apu Chowdhury, Jihong Lu, Zhanjun Jia, Jun Song, Xiaoxing Yin*, Ying Sun*. Microsomal Prostaglandin E Synthase 2 Deficiency Is Resistant to Acetaminophen-Induced Liver Injury. Arch Toxicol. 2019 Oct;93(10):2863-2878.

7.    Xueyan Zhou, Chunxia Chen, Di Yin, Feng Zhao, Zejun Bao, Yun Zhao, Xi Wang, Wei Li, Tao Wang, Yingliang Jin, Dongmei Lv, Qian Lu, Xiaoxing Yin*. A Variation in the ABCC8 Gene Is Associated with Type 2 Diabetes Mellitus and Repaglinide Efficacy in Chinese Type 2 Diabetes Mellitus Patients. Intern Med. 2019 Aug 15;58(16):2341-2347.

8.    Yang H, Yang T, Heng C, Zhou Y, Jiang Z, Qian X, Du L, Mao S, Yin X*, Lu Q*. Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress and lipid metabolism in db/db mice. Phytother Res. 2019,33(12):3140-3152.

9.    Lu Q, Chen YB, Yang H, Wang WW, Li CC, Wang L, Wang J, Du L, Yin XX*. Inactivation of TSC1 promotes epithelial-mesenchymal transition of renal tubular epithelial cells in mouse diabetic nephropathy. Acta Pharmacol Sin. 2019,40(12):1555-1567.

10.Lu Q, Wang WW, Zhang MZ, Ma ZX, Qiu XR, Shen ML, Yin XX*. ROS induces epithelial‑mesenchymal transition via the TGF‑β1/PI3K/Akt/mTOR pathway in diabetic nephropathy. Exp Ther Med. 2019; 17:835-846.

11.Yun Wang, Jing Ni, Ce Gao, Liming Xie, Lingyan Zhai, Guiyun Cui, Xiaoxing Yin*. Mitochondrial Transplantation Attenuates Lipopolysaccharide- Induced Depression-Like Behaviors. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13; 93:240-249.

12.Xiaoke Gu, Yanfei Jiang, Jing Chen, Yinpeng Zhang, Mingyu Guan, Xin Li, Qingqing Zhou, Qian Lu, Jingying Qiu, Xiaoxing Yin*. 4Synthesis and Biological Evaluation of Bifendate Derivatives Bearing Acrylamide Moiety as Novel Antioxidant Agents. Eur J Med Chem. 2019 Jan 15; 162:59-69.

13.Wang Y, Ni J, Zhai L, Gao C, Xie L, Zhao L, Yin X*. Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors. J Affect Disord. 2019 Jan 1; 242:52-59.

14.Lu Q, Hao M, Wu W, Zhang N, Isaac AT, Yin J, Zhu X, Du L, Yin X*. Antidiabetic cataract effects of GbE, Rutin and Quercetin are mediated by the Inhibition of Oxidative Stress and Polyol Pathway. Acta Biochim Pol. 2018;65(1):35-41.

15.Xia Zhu, Ya-Qin Cheng, Qian Lu, Lei Du, Xiao-Xing Yin*, Yao-Wu Liu*. Enhancement of Glyoxalase 1, a Polyfunctional Defense Enzyme, by Quercetin in the Brain in Streptozotocin-Induced Diabetic Rats. Naunyn Schmiedebergs Arch Pharmacol. 2018 Nov;391(11):1237-1245.

16.Meng-Ya Zhang, Yu Li, Shen-Yuan Yin, Li Kong, Xiao-Li Liu, Xiao-Xing Yin*, Yao-Wu Liu*. Sarsasapogenin Suppresses Aβ Overproduction Induced by High Glucose in HT-22 Cells. Naunyn Schmiedebergs Arch Pharmacol. 2018 Feb;391(2):159-168.

17.Lu Q, Zhou Y, Hao M, Li C, Wang J, Shu F, Du L, Zhu X, Zhang Q, Yin X*. The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy. Mol Cell Endocrinol. 2018; 473:31-43.

18.Yanyan Yu, Yuan Yang, Fan Wang, Jinhua Ding, Si Meng, Chenglin Li, Daoquan Tang, Xiaoxing Yin*. Functional and Biocompatible Polymeric Ionic Liquid (PIL) - Decorated Immunomagnetic Nanospheres for the Efficient Capture of Rare Number CTCs. Anal Chim Acta. 2018 Dec 31; 1044:162-173.

19.Yanyan Yu, Yuan Yang, Jinhua Ding, Si Meng, Chenglin Li, Xiaoxing Yin*. Design of a Biocompatible and Ratiometric Fluorescent Probe for the Capture, Detection, Release, and Reculture of Rare Number CTCs. Anal Chem. 2018 Nov 20;90(22):13290-13298.

20.Han X, Min M, Wang J, Bao Z, Fan H, Li X, Adelusi TI, Zhou X*, Yin X*. Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat. J Neurosci Res. 2018 Jan;96(1):138-150.

21.Xiaoke Gu, Yanfei Jiang, Yingying Qu, Jing Chen, Dingding Feng, Chenglin Li, Xiaoxing Yin*. Synthesis and Biological Evaluation of Bifendate Derivatives Bearing 6,7-dihydro-dibenzo[c,e]azepine Scaffold as Potential P-glycoprotein and Tumor Metastasis Inhibitors. Eur J Med Chem. 2018 Feb 10; 145:379-388.

22.Yangyang Zhu, Tian Teng, Hu Wang, Hao Guo, Lei Du, Baoxue Yang, Xiaoxing Yin*, Ying Su*. Quercetin Inhibits Renal Cyst Growth in Vitro and via Parenteral Injection in a Polycystic Kidney Disease Mouse Model. Food Funct. 2018 Jan 24;9(1):389-396.

23.Hu Wang, Yang-Yang Zhu, Li Wang, Tian Teng, Meng Zhou, Shu-Guang Wang, Yi-Zhu Tian, Lei Du, Xiao-Xing Yin*, Ying Sun*. Mangiferin Ameliorates Fatty Liver via Modulation of Autophagy and Inflammation in High-Fat-Diet Induced Mice. Biomed Pharmacother. 2017 Dec; 96:328-335.

24.Du L, Hao M, Li C, Wu W, Wang W, Ma Z, Yang T, Zhang N, Isaac AT, Zhu X, Sun Y, Lu Q*, Yin X*. Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway. Mol Cell Endocrinol. 2017,452:44-56.

25.Yanyan Yu, Peng Wang, Xiaodan Zhu, Qiwen Peng, Yi Zhou, Tianxiao Yin, Yixin Liang, Xiaoxing Yin*. Combined Determination of Copper Ions and β-Amyloid Peptide by a Single Ratiometric Electrochemical Biosensor. Analyst. 2017 Dec 18;143(1):323-331.

26.Li Qun Jiang, Ting Yu Wang, Thomas J Webster, Hua-Jian Duan, Jing Ying Qiu, Zi Ming Zhao, Xiao Xing Yin, Chun Li Zheng. Intracellular Disposition of Chitosan Nanoparticles in Macrophages: Intracellular Uptake, Exocytosis, and Intercellular Transport. Int J Nanomedicine. 2017 Aug 31; 12:6383-6398.

27.Deng-Pan Wu, Tian-Yu Lin, Li-Ru Bai, Jin-Lan Huang, Yan Zhou, Nan Zhou, Sheng-Lei Zhong, Shan Gao, Xiao-Xing Yin*. Enhanced Phototoxicity of Photodynamic Treatment by Cx26-composed GJIC via ROS-, Calcium- And Lipid Peroxide-Mediated Pathways. J Biophotonics. 2017 Dec;10(12):1586-1596.

28.Cheng-Hua Zhou, Ming-Xing Zhang, Sha-Sha Zhou, Huan Li, Jian Gao, Lei Du, Xiao-Xing Yin*. SIRT1 Attenuates Neuropathic Pain by Epigenetic Regulation of mGluR1/5 Expressions in Type 2 Diabetic Rats. Pain. 2017 Jan;158(1):130-139.

29.Yao-Wu Liu, Ya-Qin Cheng, Xiao-Li Liu, Yun-Chao Hao, Yu Li, Xia Zhu, Fan Zhang, Xiao-Xing Yin*. Mangiferin Upregulates Glyoxalase 1 Through Activation of Nrf2/ARE Signaling in Central Neurons Cultured With High Glucose. Mol Neurobiol. 2017 Aug;54(6):4060-4070.

30.Dan Yang, Xin Cao, Fan Wang, Haijing Jiang, Dingding Feng, Hao Guo, Lei Du, Yingliang Jin, Yansu Chen, Xiaoxing Yin*, Chenglin Li*. LFG-500, a Novel Synthetic Flavonoid, Suppresses Epithelial-Mesenchymal Transition in Human Lung Adenocarcinoma Cells by Inhibiting NLRP3 in Inflammatory Microenvironment. Cancer Lett. 2017 Aug 1; 400:137-148.