师资队伍
教授
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刘耀武

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发布时间:2020年05月26日
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刘耀武,教授,博士,硕士生导师

科学研究方向

糖尿病及其慢性并发症防治研究

联系方式

电 话:0516-83262107

Emailw54615@163.com

通 讯:江苏省徐州市云龙区铜山路209号,221004

个人简历

江苏省高校“青蓝工程”中青年学术带头人,江苏省“六大人才高峰”高层次人才,江苏省“333工程”第三层次人才。中国药理学会会员,江苏省药理学会青年工作委员会副主任委员。20036月进入徐州医科大学从事教学和科研工作。20096月获得中国药科大学药物代谢动力学博士学位。20109月至201212月于南京军区南京总医院从事博士后研究工作。20163月至20173月,为香港中文大学访问学者。目前主要研究方向:糖尿病脑病和肾病的发病机制及其防治药物研究。近几年,主持完成了国家自然科学基金面上项目、江苏省自然科学基金项目、中国博士后科学基金项目、江苏省“六大人才高峰”项目等。工作以来,在国内外重要学术刊物上以通讯作者或第一作者发表学术论文30余篇,其中SCI收录论文近30篇,SCI他引超过800次,单篇引用最高97次。获得徐州市科技奖一等奖1项(R2);申请国家发明专利3项(授权2项)。副主编实验教材1部,参编学术著作2部,实验教材1部。担任Frontiers in Endocrinology-Section Renal EndocrinologyAssociate Editor;为SCI期刊Br J Pharmacol, Biochem Pharmacol, Phytomedicine, Phytother Res, Food & Function等国际杂志审稿人。

承担科研课题

1.    国家自然科学基金面上项目,81371210Nrf2/ARE调控的乙二醛酶1在糖尿病脑病防治中的作用及芒果苷的效应和机制,2014.01-2017.1270万元,主持。

2.    江苏省“六大人才高峰” 项目C类,2014-YY-020,芒果苷抗糖尿病脑病的药理学基础研究,2015.01-2017.125万元,主持。

3.    江苏省高校“青蓝工程”中青年学术带头人项目,2014年,2014.07-2017.0710万元,负责人。

4.    江苏省自然科学基金面上项目,BK2011208,知母提取物抗糖尿病大鼠认知功能障碍作用及其物质基础研究,2012.01-2014.128万元,主持。

5.    中国博士后科学基金二等资助,201150M1576PPARγ激活在抗糖尿病大鼠认知功能障碍中的作用,2012.01-2013.123万元,主持。

近五年代表性论文、专著

1.    Ting-Ting Huang, Pan-Pan Gu, Ting Zheng, Ling-Shan Gou, Yao-Wu Liu*. Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2. Food Funct. 2022 Jan 4; 13(1): 242-254.

2.    Yu-Meng Zhang, Ting Zheng, Ting-Ting Huang, Pan-Pan Gu, Ling-Shan Gou, Teng-Fei Ma, Yao-Wu Liu*. Sarsasapogenin attenuates Alzheimer-like encephalopathy in diabetes. Phytomedicine. 2021 Jul 23;91: 153686.

3.    Xia Zhu, Yu-Meng Zhang, Meng-Ya Zhang, Ya-Jing Chen, Yao-Wu Liu*. Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway. Metab Brain Dis. 2021 Jul 17;36(7): 1969-1983.

4.    Xi-Zhi Li, Hong Jiang, Yi-Qi Liu, Jia-Wei Tang, Jia-Sen Shi, Xiu-Juan Yu, Xue Wang, Lei Du, Qian Lu, Cheng-Lin Li, Yao-Wu Liu*, Xiao-Xing Yin*. Sarsasapogenin restores podocyte autophagy in diabetic nephropathy by targeting GSK3β signaling pathway. Biochem Pharmacol. 2021 Jul 9;192:114675.

5.    Li Kong, Yue Liu, Yu-Meng Zhang, Yu Li, Ling-Shan Gou, Teng-Fei Ma, Yao-Wu Liu*. Sarsasapogenin ameliorates diabetes-associated memory impairment and neuroinflammation through downregulation of PAR-1 receptor. Phytother Res. 2021 Jun;35(6):3167-3180.

6.    Xia Zhu, Hai-Yan Liu, Yuan Liu, Ya-Jing Chen, Yao-Wu Liu*, Xiao-Xing Yin*. The antidepressant-like effects of hesperidin in streptozotocin-induced diabetic rats by activating Nrf2/ARE/glyoxalase 1 pathway. Front Pharmacol. 2020 Aug 28;11:1325.

7.    Zhuang-Zhuang Tang, Yu-Meng Zhang, Ting Zheng, Ting-Ting Huang, Teng-Fei Ma, Yao-Wu Liu*.Sarsasapogenin alleviates diabetic nephropathy through suppression of chronic inflammation by down-regulating PAR-1: In vivo and in vitro study. Phytomedicine. 2020 Aug 26;78:153314.

8.    Yue Liu, Zhuang-Zhuang Tang, Yu-Meng Zhang, Li Kong, Wei-Fen Xiao, Teng-Fei Ma, Yao-Wu Liu*. Thrombin/PAR-1 activation induces endothelial damages via NLRP1 inflammasome in gestational diabetes. Biochem Pharmacol. 2020 May; 175:113849.

9.    Ya-Jing Chen, Zhuang-Zhuang Tang, Lei Du, Yue Liu, Qian Lu, Teng-Fei Ma, Yao-Wu Liu*. A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway. Brain Res Bull. 2019; 150:160-167.

10.Ya-Jing Chen, Li Kong, Zhuang-Zhuang Tang, Yu-Meng Zhang, Yue Liu, Tao-Yun Wang, Yao-Wu Liu*. Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2/ARE/glyoxalase 1 pathway. Biomed Pharmacother. 2019;111: 1166-1175. 

11.Yao-Wu Liu*, Xiao-Li Liu, Li Kong, Meng-Ya Zhang, Ya-Jing Chen, Xia Zhu, Yun-Chao Hao. Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/ARE/glyoxalase-1 pathway mediated by phosphorylation regulation. Biomed Pharmacother. 2019;109: 2145-2154.  

12.Yao-Wu Liu*, Yun-Chao Hao*, Ya-Jing Chen, Shen-Yuan Yin, Meng-Ya Zhang, Li Kong L, Tao-Yun Wang. Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats. Phytother Res. 2018; 32(8):1574-1582.

13.Yao-Wu Liu, Ya-Qin Cheng, Xiao-Liu Liu, Yun-Chao Hao, Yu Li, Xia Zhu, Fan Zhang, Xiao-Xing Yin*. Mangiferin Upregulates Glyoxalase 1 Through Activation of Nrf2/ARE Signaling in Central Neurons Cultured with High Glucose. Mol Neurobiol. 2017; 54(6):4060-4070.

14.Yao-Wu Liu, Liang Zhang, Yu Li, Ya-Qin Cheng, Xia Zhu, Fan Zhang, Xiao-Xing Yin*. Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: in vitro and in vivo evidences. Mol Neurobiol. 2016;53(7):4972-4980.