于妍妍

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发布时间：2020年05月26日

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	于妍妍，教授，博士，博士生导师
	科学研究方向
	生物活性物质高灵敏、高精准检测技术的构建以及在重大疾病的发病机制探究和早期诊断中的应用
	联系方式
	电话：0516-83262138
	Email：yyy0916@xzhmu.edu.cn
	通讯：江苏省徐州市云龙区铜山路209号，221004

个人简历

江苏省“六大人才高峰”和“333工程”高层次人才培养对象，江苏省“青蓝工程”优秀青年骨干教师，校青年特聘教授，研究生教育优秀导师。2012年毕业于华东师范大学，同年进入徐州医科大学药物分析教研室工作。博士期间，荣获教育部“博士研究生学术新人奖”。博士毕业论文被评为上海市优秀学术论文。以第一和通讯作者在Angew. Chem. Int. Edit、Anal. Chem、Chem. Commun等高水平杂志发表SCI论文37篇，包括一区论文19篇。申请发明专利3项，其中2项已授权。获得上海市科技进步奖二等奖1项。主持国家自然科学基金面上和青年基金各1项，江苏省自然科学基金1项，江苏省高校自然科学基金重大项目1项，中国博士后科研基金多项等10余项课题。指导多名研究生获得国家奖学金。指导本科生获得大学生挑战杯省赛一等奖、全国生命科学竞赛一等奖等多项荣誉。

研究工作经历

2021年–至今，徐州医科大学，药学院药物分析教研室，教授

2019年-2020年，密歇根大学安娜堡分校，化学系，访问学者

2015年–2021年，徐州医科大学，药学院药物分析教研室，副教授

2014年–2018年，徐州医科大学生物学流动站，博士后

2012年–2015年，徐州医科大学，药学院药物分析教研室，讲师

承担科研课题

1. 徐州市重点研发计划（社会发展），KC23307，取样-检测一体化水凝胶微针贴片式传感器件用于抗生素的实时监测，2023-09-01 - 2025-08-31，10万元，主持，在研；

2. 国家自然科学基金面上项目，21675137，基于多孔聚离子液体生物载体的AD大鼠脑中复合标志物的同步在体分析，2017/01-2020/12，65万元，主持，结题；

3. 国家自然科学基金青年基金，基于系列性功能化离子液体的微渗析在体电化学分析方法的研究与应用，21205102，2013/01-2015/12，23万元，主持，结题；

4. 江苏省自然科学基金，BK20161170，纳米级超微修饰电极对AD中多种复合标志物的同步在体分析，2016/07-2019/06，10万元，主持，结题；

5. 江苏省自然科学基金，BK20201457，多功能MOFs复合你材料对AD小鼠神经元细胞内ATP 和Aβ寡聚体的荧光传感和成像分析，2020/09-2023/06，10万元，主持，结题；

6. 江苏省高等学校自然科学研究重大项目，17KJA350004，活体电化学技术对β-淀粉蛋白聚集化程度的定量评估，2017/07-2020/06，30万元，主持，结题；

7. 中国博士后科研基金特别资助，2016T90504，纳米级超微修饰电极对AD中多种标志物的同步在体分析，2016/04-2018/04，15万元，主持，结题；

8. 中国博士后科研基金面上项目，2015M580471，双通道纳米碳纤维电极对Aβ单体及寡聚体的在体分析，2015/01-2016/12，8万元，主持，结题；

9. 江苏省第五期“333工程”科研资助项目，纳米级超微修饰电极对AD中多种复合标志物的同步在体分析，2016/12-2018/12，4万元，主持，结题；

10. 徐州医科大学青年科技创新团队，重大疾病标志物的检测、探寻及应用，2019/01-2022/12，20万元，主持，结题；

11. 徐州医科大学优博人才项目，D2012010，微渗析在体电化学分析方法的建立及在脑神经科学中的应用，2013/06-2016/06，30万元，主持，结题。

发表论文

1. Hao Xu, Yingchun Zuo, Shuai Gao, Yuping Liu, Tingting Liu, Shiyu He, Mengjiao Wang, Lili Hu, Chenglin Li,* Yanyan Yu*, Circulating Tumor Cell Phenotype Detection and Epithelial-Mesenchymal Transition Tracking Based on Dual Biomarker Co-Recognition in an Integrated PDMS Chip, Small, 2024, 2310360 (IF: 13，一区)

2. Jinyu Gu, Liming Wang, Li Zhao, Yingchun Zuo, Shuai Gao, Hui Gu, Yinan Wang, Yanyan Yu*, Multiplex paper-based electrochemical immunosensor for the simultaneous monitoring of blood biomarkers in Alzheimer’s disease, Sens Actuators B-Chem., 2024, 406, 135456 (IF: 8，一区)

3. Yifan Zuo, Wenwen Lu, Yi Xia, Jiali Meng, Yi Zhou, Yang Xiao, Liang Zhu, Duanjiao Liu, Shenhao Yang, Yuqing Sun, Chenglin Li,* Yanyan Yu*, Glucometer Readout for Portable Detection of Heterogeneous Circulating Tumor Cells in Lung Cancer Captured on a Dual Aptamer Functionalized Wrinkled Cellulose Hydrogel Interface, ACS Sens., 2023, 8, 187-196. (IF: 9.618，一区)

4. Yuanyuan Hu, Xinguang Zhou, Liming Wang, Jinyu Gu, Yingchun Zuo, Li Zhao, Wenwen Lu, Yanyan Yu*, A liposome-based aptasensor integrated with competitive reaction enabling portable and electrochemical detection of Aβ oligomer, Biosens. Bioelectron., 2023, 225, 115108. (IF: 12.545，一区Top)

5. Yifan Zuo, Yi Xia, Wenwen Lu, Yue Li, Yang Xiao, Shuai Gao, Zhiyi Zhou, Hao Xu, Xingqing Feng, Chenglin Li*, Yanyan Yu*, A multifunctional black phosphorus nanosheets based immunomagnetic bio-interface for heterogenous circulating tumor cell capture and simultaneous self-identification in gastric cancer patients, Nanoscale., 2023, 15, 3872-3883. (IF: 8.307，二区)

6. Liang Ji, Xinguang Zhou, Runduo Liu, Liming Wang, Yuanyuan Hu, Jinyu Gu, Zhe Li, Chenglin Li, Tonghui Huang* , Yanyan Yu*, Design of a selective and water-soluble fluorescent probe targeting Tau fibrils for intracellular and in vivo imaging, Sensor Actuat B-Chem., 2023, 380, 133415. (IF: 9.221，一区)

7. Chenglin Li, Rui Li, Xueyuan Wu, Yifan Zuo, Guixiang Xiong, Meng Huang, Yuqing Sun, Rong Liao, Yang Xiao, Lili Hu, Chao Gao, Yanyan Yu*, Capture of Heterogeneous Circulating Tumor Cells in Colorectal Cancer Patients on an Immunomagnetic and Anti-Nonspecific Adsorption Platform, Anal. Chem., 2022, 94, 15240-15249. (IF: 8.008，一区Top，自然指数期刊)

8. Zhiheng Cai, Ali Wang, Ying Wang, Zhili Qiu, Yuting Li, Hanrong Yan, Mengying Fu, Miaoyan Liu, Yanyan Yu,* Fenglei Gao*, Smart Programmable Scalable Dual-Mode Diagnostic Logic Nanoﬂare Strategy for Dual-Tumor Marker Detection, Anal. Chem., 2022, 94, 9715−9723 (IF: 8.008，一区Top，自然指数期刊)

9. Chenglin Li, Shenhao Yang, Rui Li, Shuyuan Gong, Meng Huang, Yuqing Sun, Guixiang Xiong, Dengpan Wu, Miaojin Ji, Yan Chen, Chao Gao, Yanyan Yu*, Dual aptamer targeted immunomagnetic nanoparticles to accurately explore the correlations between circulating tumor cells and gastric cancer, ACS Appl. Mater. Interfaces., 2022, 14, 7646-7658. (IF: 10.383，一区)

10. Xinran Shi, Liang Ji, Yuanyuan Hu, Jinyu Gu, Liming Wang, Wenwen Lu, Jiali Meng, Yan Du, Lingzhong Huang, Dongxia Nie*, Yanyan Yu*, Dual-responsive zeolitic imidazolate framework-90 for the combined detection and intracellular imaging of ATP and ROS, Sensor Actuat B-Chem., 2022, 363, 131848. (IF: 9.221，一区)

11. Liang Zhu, Xingqing Feng, Shenhao Yang, Jianyun Wang, Yixin Pan, Jinhua Ding, Chenglin Li, Xiaoxing Yin*, Yanyan Yu*, Colorimetric detection of immunomagnetically captured rare number CTCs using mDNA-wrapped single-walled carbon nanotubes, Biosens. Bioelectron. 2021, 172, 112780. (IF:10.618，一区Top)

12. Chenglin Li, Xingqing Feng, Shenhao Yang, Hao Xu, Xiaoxing Yin,* Yanyan Yu*, Capture, Detection, and Simultaneous Identiﬁcation of Rare Circulating Tumor Cells Based on a Rhodamine 6G-Loaded MetalOrganic Framework, ACS Appl. Mater. Interfaces., 2021, 13, 52406-52416. (IF:10.383，一区)

13. Xueyan Yan, Yixin Pan, Liang Ji, Jinyu Gu, Yuanyuan Hu, Yi Xia, Chenglin Li, Xinguang Zhou, Dongzhi Yang, Yanyan Yu*, Multifunctional metal-organic framework as a versatile nanoplatform for Aβ oligomer imaging and chemo-photothermal treatment in living cells, Anal. Chem., 2021, 93, 13823-13834. (IF: 8.008，一区Top，自然指数期刊)

14. Jing Lu, Liang Ji, Yanyan Yu*, Rational design of a selective and sensitive “turn-on” ﬂuorescent probe for monitoring and imaging hydrogen peroxide in living cells, RSC Adv., 2021, 11, 35093 (IF:4.036，三区)

15. Qiwen Peng, Xinran Shi, Xueyan Yan, Liang Ji, Yuanyuan Hu, Guoyue Shi, Yanyan Yu*, Electrochemical Strategy for Analyzing the Co-evolution of Cu²⁺and • OH Levels at the Early Stages of Transgenic AD Mice, ACS Appl. Mater. Interfaces., 2020, 12, 42595-42603. (IF:9.229，二区)

16. Qiwen Peng, Xueyan Yan, Xinran Shi, Shanshan Ou, Hui Gu, Xiaoxing Yin*, Guoyue Shi, Yanyan Yu*, In vivo monitoring of superoxide anion from Alzheimer's rat brains with functionalized ionic liquid polymer decorated microsensor, Biosens. Bioelectron. 2019, 144, 111665-111672. (IF: 10.257，一区Top)

17. Yanyan Yu, Tianxiao Yin, Qiwen Peng, Lingna Kong,Chenglin Li, Daoquan Tang*,Xiaoxing Yin*, Simultaneous Monitoring of Amyloid-β (Aβ) Oligomers and Fibrils for Effectively Evaluating the Dynamic Process of Aβ Aggregation, ACS Sens. 2019, 4 (2), 471-478. (IF: 7.333，一区)

18. Yanyan Yu, Yuan Yang, Jinhua Ding, Si Meng, Chenglin Li*, Xiaoxing Yin*, Design of A Biocompatible and Ratiometric Fluorescent probe for the Capture, Detection, Release and Reculture of rare number CTCs, Anal. Chem. 2018, 90, 13290-13298. (IF: 6.35，一区Top，自然指数期刊)

19. Yanyan Yu, Yuan Yang, Fan Wang, Jinhua Ding, Si Meng, Chenglin Li, Daoquan Tang, Xiaoxing Yin*, Functional and biocompatible polymeric ionic liquid (PIL) - Decorated immunomagnetic nanospheres for the efﬁcient capture of rare number CTCs, Anal Chim Acta., 2018, 1044, 162-173. (IF: 5.256，一区)

20. Fenglei Gao, Yao Yao, Jing Wu, Lin Cui, Yu Zhang, Deqin Geng,* Daoquan Tang*, Yanyan Yu* , A robust ﬂuorescent probe for detection of telomerase activity in vitro and imaging in living cells via telomerase-triggering primer extension to desorb DNA from graphene oxide, Analyst, 2018, 143, 3651. (IF: 4.02，二区)

21. Yanyan Yu,* Peng Wang, Xiaodan Zhu, Qiwen Peng, Yi Zhou, Tianxiao Yin, Yixin Liang, Xiaoxing Yin*, Combined determination of copper ions and β-amyloid peptide by a single ratiometric electrochemical biosensor, Analyst, 2018, 143, 323. (IF: 4.02，二区)

22. Yin Zhang, Si Meng, Jinhua Ding, Qiwen Peng, Yanyan Yu*, Transition metal-coordinated graphitic carbon nitride dots as a sensitive and facile ﬂuorescent probe for β-amyloid peptide detection, Analyst, 2019, 144, 504. (IF: 3.978，二区)
(23) Yanyan Yu, Chao Yu, Tianxiao Yin, Shanshan Ou, Xiaoyu Sun, Xiangru Wen, Lin Zhang, Daoquan Tang, Xiaoxing Yin*, Functionalized poly (ionic liquid) as the support to construct a ratiometric electrochemical biosensor for the selective determination of copper ions in AD rats, Biosens. Bioelectron. 2017, 87, 278-284. (IF: 8.17，一区TOP)

23. Yanyan Yu, Lin Zhang,‡ b Xiao-yu Sun, b Cheng-lin Li, b Yu Qiu, c Hao-peng Sun,d Dao-quan Tang, abYao-wu Liu band Xiao-xing Yin*, A sensitive colorimetric strategy for monitoring cerebral b-amyloid peptides in AD based on dual-functionalized gold nanoplasmonic particles, Chem.Commun., 2015, 51, 8880-8883 (IF: 6.567, 自然指数期刊)

24. Yanyan Yu, Xiaoyu Sun, Daoquan Tang, Chenglin Li, Lin Zhang, Dongxia Nie, Xiaoxing Yin*, Guoyue Shi*, Gelsolin bound β amyloid peptides (1–40/1–42) : Electrochemical evaluation of levels of soluble peptide associated with Alzheimer's disease, Biosens. Bioelectron. 2015, 68, 115-121. (IF: 6.41，一区TOP)

25. Yanyan Yu, Lin Zhang, Chenglin Li, Xiaoyu Sun, Daoquan Tang, Guoyue Shi*, A Method for Evaluating the Level of Soluble β-Amyloid (1–40/1–42) in Alzheimer’s Disease Based on the Binding of Gelsolin to β-Amyloid Peptides, Angew. Chem. Int. Ed., 2014, 53, 12832-12835. (IF: 11.26，一区Top)

授权专利

1. 于妍妍，顾瑾毓，汪礼明，赵丽，左颖春。检测阿尔茨海默症的纸基电化学传感器的制备方法及应用，2024-01-23，中国，ZL 202310260178.9.

2. 印晓星，于妍妍，郁超，汤道权，杨渊，李成林。聚离子液体磁性纳米复合物及其对痕量循环肿瘤细胞特异性富集和检测的应用，2017-08-11，中国，ZL 201710686464.6.

人才称号及获奖

1. 江苏省第五期“333高层次人才培养工程”第三层次培养对象，2016年；

2. 江苏省“六大人才高峰”高层次人才C类，2016年；

3. 江苏省高校“青蓝工程”优秀青年骨干教师培养对象，2014年；

4. 第十八届“挑战杯”全国大学生课外学术科技作品竞赛江苏省一等奖：于妍妍（第一指导老师），郭栋，李成林，2023年；

5. 第八届全国大学生生命科学竞赛指导教师一等奖：异质型循环肿瘤细胞同步捕获、鉴别和检测一体化研究，于妍妍（第一指导老师），李成林，2023年；

6. 于妍妍，上海市优秀博士毕业论文，微渗析活体取样-电化学在线分析系统对生命信息分子实时检测的研究与应用，2013年。