周雪妍

个人简历

江苏省333高层次人才、“六大人才高峰”高层次人才、江苏省“青蓝工程”优秀青年骨干教师。现任徐州医科大学药学院院长、江苏省药理学会理事、江苏省药理学会临床前药理专委会副主委、中国药理学会药代青委会常务委员、中国药理学会抗炎免疫药理青委会常务委员。主持国家自然科学基金面上项目等科研项目多项，“代谢信号分子与药物靶标发现”相关研究成果获2019年度江苏省医学新技术引进奖一等奖，2021年江苏省科学技术奖一等奖。“药学人才培养”相关教学成果获江苏省教学成果二等奖。

承担科研课题

1. 国家自然科学基金面上项目，82173883，YY1-UGT2B7-雌激素代谢轴调控乳腺肿瘤炎性微环境介导他莫昔芬耐药的作用与机制，2022/01~2025/12，55万元，在研，主持

2. 江苏省中医药管理局, 科技创新, MS2023175, 基于性激素内稳态调控的酸枣仁地黄汤辅助治疗多囊卵巢综合征的作用与机制, 2024-01~2026-12, 10万元, 在研, 主持

3. 徐州市推动科技创新专项资金项目，KC21010，YY1-UGT2B7-雌激素代谢轴调控乳腺肿瘤炎性微环境介导他莫昔芬耐药的作用与机制，2021/09~2023/08，5万元，在研，主持

4. 校-企联合研发基金项目，MSCs在STZ联合高脂饮食诱导的Ⅱ型糖尿病肾病大鼠模型中归巢实验研究，2024-01~2026-12，20万元，在研，主持

5. 校青年科技创新团队项目，干细胞成药性研究，2024-01~2025-12，25万元，在研，主持

6. 江苏省自然科学基金面上项目，BK20181470，基于"UGT1A8-雌激素-ER"作用轴的乳腺癌他莫昔芬耐药机制及新化合物AB-38b的逆转耐药作用，2018/07 ~ 2021/06, 10万元，结题，主持

7. 江苏省高校自然科学重大项目，18KJA350002，基于雌激素代谢的AB-38b抗乳腺癌耐药作用及机制，2018/07~2021/06, 30万元，结题，主持

8. 国家自然科学基金青年项目，81403001，UGT功能失调诱导的雌激素代谢紊乱在乳腺癌发生中的作用，2015/01~2017/12，23万元，结题，主持

近五年代表性论文、专著

1. Xu J, Zhou Y, He S, Wang Y, Ma J, Li C, Liu Z, Zhou X（通讯作者）. Activation of the YY1-UGT2B7 Axis Promotes Mammary Estrogen Homeostasis Dysregulation and Exacerbates Breast Tumor Metastasis. Drug Metab Dispos. 2024 Apr 16;52(5):408-421.

2. Zhou Y, Yin Z, Cui J, Wang C, Fu T, Adu-Amankwaah J, Fu L, Zhou X（通讯作者）. 16α-OHE1 alleviates hypoxia-induced inflammation and myocardial damage via the activation of β2-Adrenergic receptor. Mol Cell Endocrinol. 2024 Jun 1:587:112200.

3. Zhou Y, Li Y, Chen G, Guo X, Gao X, Meng J, Xu Y, Zhou N, Zhang B, Zhou X（通讯作者）.. ACSL1-Mediated Fatty Acid β-Oxidation Enhances Metastasis and Proliferation in Endometrial Cancer. Front Biosci (Landmark Ed).2024 Feb 6;29(2):66.

4. Guo X, Cao Y, He Q, Chen L, Wang Q, Zhang J, Lv W, Zhang B, Zhou X（通讯作者）. Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome. Hum Cell. 2024 May;37(3):689-703.

5. Zhou N, Lv W, Chen L, Chen K, He Q, Xie G, Ma J, Cao Y, Zhang B, Zhou X（通讯作者）.. Jujuboside A Attenuates Polycystic Ovary Syndrome Based on Estrogen Metabolism Through Activating AhR-mediated CYP1A2 Expression. Reprod Sci. 2024 Mar 18.

6. Zhou W, Ma J, Zhao H, Wang Q, Guo X, Chen L, Cao Z, Xu J, Zhang B, Zhou X（通讯作者）. Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell. Mol Cell Proteomics. 2023 Apr;22(4):100520.

7. Zhixiang Hao, Jiahao Xu, Han Zhao, Wei Zhou, Zhao Liu, Shiqing He, Xiaoxing Yin, Bei Zhang, Zhongjian Wang, Xueyan Zhou（通讯作者）. The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation. BMC Pharmacol Toxicol. 2022 May 31;23(1):33.

8. Zhao F, Hao Z, Zhong Y, Xu Y, Guo M, Zhang B, Yin X, Li Y, Zhou X（通讯作者）. Discovery of breast cancer risk genes and establishment of a prediction model based on estrogen metabolism regulation. BMC Cancer. 2021 Feb 25;21(1):194.

9. Zhou X, Xu Y, Yin D, Zhao F, Hao Z, Zhong Y, Zhang J, Zhang B, Yin X. Type 2 diabetes mellitus facilitates endometrial hyperplasia progression by activating the proliferative function of mucin O-glycosylating enzyme GALNT2. Biomed Pharmacother. 2020 Nov; 131:110764.

10.Zhao F, Wang X, Wang Y, Zhang J, Lai R, Zhang B, Zhou X（通讯作者）. The function of uterine UDP-glucuronosyltransferase 1A8 (UGT1A8) and UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in endometrial cancer based on estrogen metabolism regulation. Hormones-International Journal of Endocrinology and Metabolism. 2020 Sep;19(3):403-412.

11.Zhou X, Chen C, Zhong Y, Zhao F, Hao Z, Xu Y, Lai R, Shen G, Yin X. Effect and mechanism of vitamin D on the development of colorectal cancer based on intestinal flora disorder. J Gastroenterol Hepatol. 2020 Jun;35(6):1023-1031.

12.Zhou X,;Yun Zhao; Juan Wang; Xi Wang; Chunxia Chen; Di Yin; Feng Zhao; Jiale Yin; Meng Guo; Longzhen Zhang; Lei Du; Bei Zhang; Xiaoxing Yin ; Resveratrol represses estrogeninduced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation., Biochem Pharmacol., 2018.09, 155: 252-263

13.Zhou X, Ziqiang Zheng; Chang Xu; Juan Wang; Mengjun Min; Yun Zhao; Xi Wang; Yinhan Gong; Jiale Yin; Meng Guo; Dong Guo; Junnian Zheng; Bei Zhang; Xiaoxing Yin. Disturbance of Mammary UDP-Glucuronosyltransferase Represses Estrogen Metabolism and Exacerbates Experimental Breast Cancer. J Pharm Sci 2017 Aug;106(8):2152-2162.

14. Zhou X,Qiuxiang Zhu, Xiaowen Han, Renguo Chen, Yaowu Liu, Hongbin Fan, Xiaoxing Yin. Quantitative-profiling of neurotransmitter abnormalities in the disease progression of experimental diabetic encephalopathy rat. Can J Physiol Pharmacol. 2015 Nov;93(11):1007-13.

15.Zhou X#, Cao L#, Jiang C#, Xie Y, Cheng X, Krausz KW, Qi Y, Sun L, Shah YM, Gonzalez FJ, Wang G, Hao H. PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. Nat Commun. 2014 Sep 3; 5:4573.

授权发明专利

1. 周雪妍; 陈琳娜; 徐嘉浩; 张永丽; 翟语桐; 张蓓; 曹义捐 ; 酸枣仁皂苷A在治疗多囊卵巢综合征中 的应用, 2022-10-21, 中国, ZL 2022 1 1294740.1

2. 周雪妍; 印晓星; 张蓓; 徐吟雪; 尹弟 ; GALNT2作为子宫内膜增生或子宫内膜癌诊治标志物的应用, 2020-10-30, 中国, ZL202010383884.9

3. 周雪妍; 郭晓莉; 高剑; 印晓星; 张蓓; 徐吟雪 ; 一种靶向ACSL1的小分子药物及其在子宫内膜癌中 的应用, 2021-8-6, 中国, ZL 2021 1 0902537. 7

4. 周雪妍; 曹中辉; 高剑; 高笑; 孟瑾; 周业权 ; 化合物EP9在制备抗糖尿病肾病肾纤维化的药物中的 应用, 2022-11-29, 中国, ZL 2022 1 1509636.X