邱净英

个人简历

2006年毕业于沈阳药科大学，获理学学士学位，2012年毕业于贵州大学（贵州省中国科学院天然产物化学重点实验室），获理学博士学位，同年进入徐州医科大学药学院药物分析教研室任职。2020年于美国明尼苏达大学交流访学一年。近年来研究方向为抗病毒药物分子的设计、合成及生物活性研究，先后主持国家自然科学基金青年基金、江苏省自然科学基金青年基金、江苏省自然科学基金面上项目等科研项目。以第一或通讯作者在European Journal of Medicinal Chemistry、Bioorganic & Medicinal Chemistry等杂志发表SCI论文20余篇，申请专利5项（已授权3项）。主要承担研究生《药物光谱分析选论》以及药学、临床药学、药物制剂等本科专业《药物分析》、《分析化学》等课程的理论及实验教学。

承担科研课题

1.      国家自然科学基金青年基金项目，81703359，基于药效团融合的新型抗HBV药物的设计、合成及生物活性研究，2018-01至2020-12，19.9万元，主持；

2.      江苏省自然科学基金面上项目，BK20231180，靶向TLR7/8和核心蛋白的新型苯并咪唑类化合物的设计、合成及抗HBV活性研究，2023-09至2026-08，10万元，主持；

3.      江苏省自然科学基金面上项目，BK20181151，具有双重作用机制的药效团融合型抗HBV化合物的设计、合成及生物活性研究，2018-07至2021-06，10万元，主持；

4.      江苏省自然科学基金青年基金项目，BK20140223，多靶点抗乙肝病毒药物的设计、合成及生物活性研究，2014-07至2017-07，20万元，主持；

5.      徐州市科技计划项目，靶向核心蛋白和TLR7/8的新型喹唑啉酮类化合物的设计、合成及抗HBV活性研究，KC21011，6万元，2021-09至2023-08，主持；

6.      徐州医学院优秀人才科研启动基金，新型苯基丙酰胺类化合物的设计、合成及抗HBV活性研究，2013.06-2016.06，10万元，主持。

近五年代表性论文、专著

1.      Shuqiong Li^#, Lihua Yang^#, Qiuting Xu, Xincheng Li, Jiangyan Zhao, Zhoupeng Tan, Xiaoke Gu^*, Jingying Qiu^*, Exploration of 1-(indolin-1-yl)-2-(thiazol-2-yl)ethan-1-one derivatives as novel anti-HBV agent with potential TLR7-agonistic effect, European Journal of Medicinal Chemistry, 2024, 275, 116575. (IF: 6.0, 一区)

2.      Jingying Qiu^#, Yueting Zou^#, Shuqiong Li, Lihua Yang, Zibin Qiu, Fanyun Kong^*, Xiaoke Gu^*, Discovery of benzimidazole substituted 1, 2, 4-oxadiazole compounds as novel anti-HBV agents with TLR8-agonistic activities, European Journal of Medicinal Chemistry, 2022, 244, 114833. (IF: 7.088, 一区)

3.      Jingying Qiu^#, Qingqing Zhou^#, Yueting Zou, Shuqiong Li, Lihua Yang, Wang Chen, Jian Gao^*, Xiaoke Gu^*, Design and synthesis of novel quinazolinone derivatives as anti-HBV agents with TLR8 agonist effect, European Journal of Medicinal Chemistry, 2022, 231, 114159. (IF: 7.088, 一区)

4.      Jingying Qiu^#, Yueting Zou^#, Qingchuan Liu, Chunyu Jiang, Qingqing Zhou, Shuqiong Li, Wang Chen, Zheng Li, Xiaoke Gu^*, Synthesis and evaluation of novel quinazolinone derivatives as potential anti-HCC agents, Chemistry & Biodiversity, 2022, 19, e202100766. (IF: 2.9, 三区)

5.      Xiaoke Gu^#, Yinpeng Zhang^#, Yueting Zou, Xin Li, Mingyu Guan, Qingqing Zhou, Jingying Qiu^*, Synthesis and evaluation of new phenyl acrylamide derivatives as potent non-nucleoside anti-HBV agents, Bioorganic & Medicinal Chemistry, 2021, 29, 115892. (IF: 3.641, 三区)

6.      Xiaoke Gu^{#, *}, Mingyu Guan^#, Chunyu Jiang, Qinghua Song, Xin Li, Nan Sun, Jing Chen, Jingying Qiu^*, Assessment of Thiosemicarbazone-Containing Compounds as Potential Antileukemia Agents against P-gp Overexpressing Drug Resistant K562/A02 Cells, Chemistry & Biodiversity, 2021, 18, e2000775. (IF: 2.745, 三区)

7.      Jingying Qiu^#, Qingqing Zhou^#, Yinpeng Zhang, Mingyu Guan, Xin Li, Yueting Zou, Xuan Huang, Yali Zhao, Wang Chen, Xiaoke Gu^*, Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents, European Journal of Medicinal Chemistry, 2020, 205, 112581. (IF: 6.514, 一区)

8.      Xiaoke Gu^{#, *}, Xin Li^#, Mingyu Guan, Chunyu Jiang, Qinghua Song, Nan Sun, Yueting Zou, Qingqing Zhou, Jing Chen, Jingying Qiu^*, Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells, Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127638. (IF: 2.823, 三区)

9.      Xiaoke Gu^{#, *}, Jing Chen^#, Yinpeng Zhang, Mingyu Guan, Xin Li, Qingqing Zhou, Qinghua Song, Jingying Qiu^*, Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents, European journal of medicinal chemistry, 2019, 180, 62-71. (IF: 5.572, 一区)

10.  Jingying Qiu^#, Wang Chen^#, Yinpeng Zhang, Qingqing Zhou, Jing Chen, Lihua Yang, Jian Gao^*, Xiaoke Gu^*, Daoquan Tang^*, Assessment of quinazolinone derivatives as novel non-nucleoside hepatitis B virus inhibitors, European Journal of Medicinal Chemistry, 2019, 176, 41-49. (IF: 5.572, 一区)

11.  Xiaoke Gu^{#, *}, Yanfei Jiang^#, Jing Chen, Yinpeng Zhang, Mingyu Guan, Xin Li, Qingqing Zhou, Qian Lu, Jingying Qiu^*, Xiaoxing Yin^*, Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents, European Journal of Medicinal Chemistry, 2019, 162, 59-69. (IF: 5.572, 一区)