程国辉

个人简历

2015年毕业于天津医科大学药学院药学专业，获药学学士学位。2018年毕业于南开大学药学院，获得药物化学硕士学位。2021年毕业于天津大学生命科学学院，获得生物学博士学位。2021年8月，加入徐州医科大学药学院，从事教学与科研工作。研究方向为生物医用材料在疾病诊疗方向应用。主持国家自然科学基金一项，江苏省自然科学基金一项。以第一作者或通讯作者在Advanced Materials, Nano Today，Chemical Engineering Journal，ACS Macro Letters，Mater. Today Bio, Journal of Colloid and Interface Science等发表论文。

承担科研课题

1.      国家自然科学基金，32201168，核交联纳米诊疗系统用于肿瘤自增强光动力治疗研究，2023.1-2025.12，30万元，项目负责人。

2.      江苏省自然科学基金，BK20220676，核交联聚合物胶束用于肿瘤自增强光动力治疗研究，2022.7-2025.6，20万元，项目负责人。

3.      江苏省“双创博士”项目资助经费，15万，项目负责人。

4.      徐州医科大学优秀人才科研启动经费，40 万元，项目负责人。

近五年代表性论文、专著

1.      Shuang Liu, Xingyu Chen, Xiaojin Liu, Hao Zhang, Keyue Zhou, Yuting Shan, Minghui Chen*, Dan Wang*, Guohui Cheng*. A dual-modal GSH depletion and NIR-triggered nanoplatform for cascade-amplified phototherapy, Colloids Surf., B 2026, 261, 115461. 中科院一区，IF=5.6

2.      Jin Liu, Tianle Liu, Chi Zhang, Ziyou Wang, Xinyi Zhang, Chuanchuan Hao*, Dan Wang*, Guohui Cheng*. A mitochondrial-targeted nanomedicine based on hollow mesoporous silica nanoparticles for enhanced colorectal cancer therapy. Colloid Interface Sci. Commun. 2025, 66, 100833. 中科院2区，IF=4.7

3.      Minghui Chen, Hanbo Xu, Pengzhao Chang, Xueqi Li, Shuang Liu, Lingyue Xu, Kai Xu*, Guohui. Cheng*, An intelligent poly aptamer-encoded DNA nanoclew for tumor site activated mitochondria-targeted photodynamic therapy and mr imaging, Materials Today Bio 2024, 29, 101318. 中科院一区，IF=8.7

4.      Guohui Cheng, Shuang Tao, Shuang Liu, Ping Wang, Chi Zhang, Jin Liu, Chuanchuan Hao, Sheng Wang*, Dong Guo*, Bo Xu*. Glutathione-responsive polymersome with continuous glutathione depletion for enhanced photodynamic therapy and hypoxia-activated chemotherapy, ACS Macro Lett. 2024, 13, 599-606. 中科院1区，IF=5.2

5.      Ying Chen, Ziqiang Xu, Xin Wang, Xuexue Sun, Xinhui Xu, Xiao Li, and Guohui Cheng*. Highly efficient photodynamic hydrogel with AIE-active photosensitizers toward Methicillin-resistant Staphylococcus aureus ultrafast imaging and killing, ACS Biomater. Sci. Eng. 2024, 10(5):3401-3411. 中科院二区，IF=5.5

6.      Xinlu Zhang, Xu Zhang, Shutong Chen, Yongxin Liu, Chen Cao, Guohui Cheng* Sheng Wang*. Glutathione-depleting polyprodrug nanoparticle for enhanced photodynamic therapy and cascaded locoregional chemotherapy, J. Colloid Interface Sci. 2024, 670, 279-287.中科院1区，IF=9.4

7.      Benshun Tian, Yuxin Wang, Wuyue Tang, Jiali Chen, Jingwen Zhang, Siyi Xue, Shaohui Zheng, Guohui Cheng*, Bing Gu*, Minghui Chen*. Tandem CRISPR nucleases-based lateral flow assay for amplification-free miRNA detection via the designed “locked RNA/DNA” as fuels, Talanta 2024, 266:124995. 中科院1区，IF=5.6

8.      Guohui Cheng, Wei Zong, Haizhen Guo, Fuyan Li, Xu Zhang, Peng Yu, Fuxin Ren, Xinlu Zhang, Xiaoen Shi, Fei Gao*, Jin Chang*, Sheng Wang*. Programmed size-changeable nanotheranostic agents for enhanced imaging-guided chemo/photodynamic combination therapy and fast elimination, Adv. Mater. 2021, 33(21): 2100398. 中科院一区，IF=27.4

9.      Guohui Cheng, Dan Wu, Sheng Wang*, Xu Zhang, Peng Yu, Jin Chang*, Xiaoyuan Chen*. Stimuli-responsive size-changeable strategy for cancer theranostics, Nano Today 2021, 38: 101208. 中科院一区，IF=13.2

10.  Guohui Cheng, Hanjie Wang*, Chaonan Zhang, Yafeng Hao, Tiange Wang, Yingying Zhang, Yu Tian, Jin Chang*. Multifunctional nano-photosensitizer: A carrier-free aggregation-induced emission nanoparticle with efficient photosensitization and pH-responsibility, Chem. Eng. J. 2020, 390: 124447. 中科院一区，IF=13.4