杨婷婷

个人简历

2017年12月毕业中国药科大学药物科学研究院，获理学博士学位；2018年入职徐州医科大学药学院工作。主要的研究方向：1. 糖尿病并发症（肝病和肾病）的发病机制及药物防治。2. 机体代谢与疾病早期诊断及标志物研究。目前主持国家自然科学基金青年基金1项、江苏省高校自然科学基金面上项目1项、徐州医科大学优秀人才科研启动基金1项。近五年内以第一作者或通讯作者在Metabolism、 Phytomedicine、 Cell Biol Toxicol、 Food & Function等杂志发表SCI收录论文15篇（中科院一区7篇，二区5篇）。

承担科研课题

1.      国基自然科学基金青年基金，81903689，基于肠道FXR/TGR5信号通路的肠道菌群调控2型糖尿病合并非酒精性脂肪性肝病肝细胞糖脂代谢的作用机制，2020. 01 -2022. 12，21万，主持

2.      江苏省高校自然科学基金面上项目，19KJB350006，槲皮素预防治疗2型糖尿病合并非酒精性脂肪肝病的研究，2019.08-2021.8，5万，主持

3.      徐州医科大学优博人才项目，D2018011，基于胆汁酸代谢轮廓的丁酸梭菌联合阿卡波糖缓解糖尿病肾病作用及其机制研究，2019.07-2022.06，30万，主持

近五年代表性论文、专著

1.      Yang T#, Wang Y#, Cao X#, Peng Y, Huang J, Chen L, Pang J, Jiang Z, Qian S, Liu Y, Ying C, Wang T, Zhang F, Lu Q, Yin X*. Targeting mTOR/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation. Phytomedicine. 2023, Accpet

2.      Yang T#, Hu Y#, Jiang W, Pang J, Zhou Y, Zhang H, Yin Z, Jiang Z, Qian S, Wei C, Yan M, Zhu X, Wang T, Lu Q*. YY1 was indispensable for the alleviation of quercetin on diabetic nephropathy-associated tubulointerstitial inflammation. Phytomedicine. 2023 Mar;111:154659.

3.      Yang T#, Li L#, Heng C#, Sha P, Wang Y, Shen J, Jiang Z, Qian S, Wei C, Yang H, Zhu X, Wang T, Wu M, Wang J, Lu Q, Yin X*. Sodium butyrate ameliorated diabetic nephropathy-associated tubulointerstitial inflammation by modulating tight junction of renal tubular epithelial cells. Food Funct. 2022, Accept.

4.      Liu YY, Li L, Ji B, Hao SL, Kuang XF, Cao XY, Yuan JY, Jiang ZZ, Qian ST, Wei CJ, Xu J, Yin XX, Lu Q*, Yang TT*. Jujuboside A ameliorates tubulointerstitial fibrosis in diabetic mice through down-regulating the YY1/TGF-β1 signaling pathway. Chin J Nat Med. 2022 Sep;20(9):656-668.

5.      Yang T#, Hu Y#, Chen S, Li L, Cao X, Yuan J, Shu F, Jiang Z, Qian S, Zhu X, Wei C, Wei R, Yan M, Li C, Yin X*, Lu Q*. YY1 inactivated transcription co-regulator PGC-1α to promote mitochondrial dysfunction of early diabetic nephropathy-associated tubulointerstitial fibrosis. Cell Biol Toxicol. 2022 Apr 21. doi: 10.1007/s10565-022-09711-7.

6.      Duan Z#, Yang T#, Li L, Wang X, Wei C, Xia Z, Chai Y, Huang X, Zhang L*, Jiang Z*. Comparison of bile acids profiles in the enterohepatic circulation system of mice and rats. J Steroid Biochem Mol Biol. 2022 Jun;220:106100.

7.      Yang T, Wang X, Zhou Y, Yu Q, Heng C, Yang H, Yuan Z, Miao Y, Chai Y, Wu Z, Sun L, Huang X, Liu B, Jiang Z*, Zhang L*. SEW2871 attenuates ANIT-induced hepatotoxicity by protecting liver barrier function via sphingosine 1-phosphate receptor-1-mediated AMPK signaling pathway. Cell Biol Toxicol. 2021 Aug;37(4):595-609.

8.      Yang T#, Yang H#, Heng C, Wang H, Chen S, Hu Y, Jiang Z, Yu Q, Wang Z, Qian S, Wang J, Wang T, Du L, Lu Q*, Yin X*. Amelioration of non-alcoholic fatty liver disease by sodium butyrate is linked to the modulation of intestinal tight junctions in db/db mice. Food Funct. 2020 Dec 1;11(12):10675-10689. 

9.      Yang T#，Wang X#, Yuan Z, Miao Y, Wu Z, Chai Y, Yu Q, Wang H, Sun L, Huang X, Zhang L*, Jiang Z*. Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver. Toxicol Lett. 2020 Oct 1;331:242-253.

10.  Yang T#, Heng C#, Zhou Y, Hu Y, Chen S, Wang H, Yang H, Jiang Z, Qian S, Wang Y, Wang J, Zhu X, Du L, Yin X*, Lu Q*. Targeting mammalian serine/threonine-protein kinase 4 through Yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis. Metabolism. 2020 Jul;108:154258.

11.  Yang T#, Zhou Y#, Wang H, Chen S, Shen M, Hu Y, Wang T, Liu J, Jiang Z, Wang Z, Zhu X, Qian S, Yin X, Lu Q*. Insulin exacerbated high glucose-induced epithelial-mesenchymal transition in prostatic epithelial cells BPH-1 and prostate cancer cells PC-3 via MEK/ERK signaling pathway. Exp Cell Res. 2020 Sep 1;394(1):112145.

12.  Yang T#, Huang Y#, Zhou Y, Chen S, Wang H, Hu Y, Liu J, Jiang Z, Lu Q*, Yin X*. Simultaneous quantification of oestrogens and androgens in the serum of patients with benign prostatic hyperplasia by liquid chromatography-Tandem mass spectrometry. Andrologia. 2020 Aug;52(7):e13611.

13.  Yang T, Khan GJ, Wu Z, Wang X, Zhang L*, Jiang Z*. Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases. Drug Discov Today. 2019 Jan;24(1):112-128.

14.  Yang T#, Shu F#, Yang H, Heng C, Zhou Y, Chen Y, Qian X, Du L, Zhu X, Lu Q*, Yin X*. YY1: A novel therapeutic target for diabetic nephropathy orchestrated renal fibrosis. Metabolism. 2019 Jul; 96:33-45.

15.  Yang H#, Yang T#, Heng C, Zhou Y, Jiang Z, Qian X, Du L, Mao S, Yin X*, Lu Q*. Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice. Phytother Res. 2019 Dec;33(12):3140-3152.