刘宏丽

发布者:

发布时间：2023年02月27日

浏览次数:

	刘宏丽，博士，副教授，硕士生导师
	科学研究方向
	多囊肾病相关靶标的药物发现与设计
	联系方式
	Email：hongliliu@xzhmu.edu.cn
	通讯：江苏省徐州市云龙区铜山路209号，221004

个人简历

2020年6月毕业于兰州大学药物化学生物学专业，获博士学位。2020年8月至今在徐州医科大学药学院从事教学与科研工作。主持国家自然科学基金青年项目、江苏省高校面上项目、校优秀人才启动基金。以第一或通讯作者在Nat. Commun、J Med Chem、Acta Pharmacol Sin、Br J Pharmacol等期刊发表SCI论文十余篇。

承担科研课题

1. 国家自然科学基金青年基金，22107090，2022.01-2024.12，30万，主持；

2. 江苏省高校自然科学基金面上项目，21KJB350009，2021.10-2023.09，3万，主持；

3. 徐州医科大学优秀人才启动基金，D2020036，2020.09-2023.08，20万，主持。

近五年代表性论文

1. Liu Hongli, Zhong Haiyang, Guo Dong*, Understanding drug-target residence time and the implications on drug discovery, Expert Opinion on Drug Discovery, 2026, 21(2):219-230.

2. Zhang Tianwei^#, Liu Hongli^#, You Chongzhao, Zhang Yixiao, Xu Youwei, Pan Benxun, Wu Canrong, Jin Sanshan, Yin Yuling, Wu Kai, Chen Yye, Sun Hong, Si Yuan, Tan Yangxia, Yin Wanchao, Xu H Eric*, Guo Dong^*, Jiang Yi^*. Structural insights into antagonist recognition by the vasopressin V₂ receptor. Nature Communications, 2025, 16(1):9734.

3. Zhong Haiyang^#, Zhang Zhengshuo^#, Chen Mengdan#, Liu Xuchao, Zhang Yixiao, Zhao Wenchao, Chen Yue, Fu Kequan, Yang Can, Shi Yuxin, Sun Yongzhan^*, Liu Hongli^*, Guo Dong^*, Discovery of non-benzoazacyclic V₂R antagonists for the treatment of autosomal dominant polycystic kidney disease, Journal of Medicinal Chemistry, 2025, 68(23), 25438-25455.

4. Yang, Yueyue^#, Liu Hongli^#, Yuan Haoxing, Lyu Kaikai, Zhong Haiyang, Li Yanlian, Cao Danyan, Zhao Wenchao, Zhang Haoran, Xiong Bing^*, Chen Danqi^*, Guo Dong^*, Design of Selective BRD4 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease, Journal of Medicinal Chemistry, 2025, 68(5):5257-5274.

5. Liu Hongli^#, Zhong Haiyang^#, Zhang Yixiao^#, Xue Huarui, Zhang Zhengshuo, Fu Kequan, Cao Xudong, Xiong Xiaochun^*, Guo Dong^*. Structure basis of tolvaptan binding to the vasopressin V₂ receptor. Acta Pharmacologica Sinica, 2024, 45(11):2441-2449.

6. Liu Hongli, Zhang Haoran, IJzerman Adriaan P, Guo Dong*. The translational value of ligand-receptor binding kinetics in drug discovery. British Journal of Pharmacology. 2024, 181(21):4117-4129.

7. Zhong Haiyang^#, Zhang Zhengshuo^#, Chen Mengdan^#, Chen Yue, Yang Can, Xue Yunsheng, Xu Pei^*, Liu Hongli^*. Structural Basis for Long Residence Time c-Src Antagonist: Insights from Molecular Dynamics Simulations. International Journal of Molecular Sciences. 2024, 25(19):10477.

8. Chen Mohan, Li Zheng, Sun Gang, Jin Shuang, Hao Xiyue, Zhang Chi, Liu Ling, Zhang Ling, Liu Hongli^*, Xue Yunsheng^*. Theoretical study on the free radical scavenging potency and mechanism of natural coumestans: Roles of substituent noncovalent interaction and solvent. Phytochemistry. 2023, 207:113580.