陈正平

个人简历

主要从事神经系统分子影像探针的研发，为神经系统疾病的诊断、治疗发及疗效监测提供合适的探针药物。主持完成了国家自然科学基金（4项）、江苏省科技支撑计划、江苏省自然科学基金、江苏省医学重点项目等基金国家级、省部级科研项目等多项。主持完成的科研成果包括：国家一类新药临床批件2件；国家发明专利30余项，发表SCI论文40余篇，获得华夏医学科技奖、中国商业科技奖、江苏省医学新技术奖、江苏医药科技奖等。

研究室具有独立的药物合成实验室、药物分析实验室、分子生物学实验室等，同时共享国家卫健委核医学重点实验室、江苏省分子核医学重点实验室的科研平台，具有优良的科研条件。研究室现有工作人员3人，其中正高级职称1人，副高职称2人。带教药物化学、核药学专业硕士研究生5人。研究室长期招收博士、硕士研究生，培养药学、药物化学、放射性药物领域的专业人才。

研究室承担的科研课题

1.    国家自然科学基金（82172054），氟[¹⁸F]标记的氘代tropane用于多巴胺转运体PET精准显像的实验研究，2022-2025

2.    江苏省自然科学基金（BK20201133），新型氟[¹⁸F]标记的中枢神经系统DAT显像药物的合成与实验研究，2022-2024

3.    国家自然科学基金 青年科学基金项目（C类）（82402427）, 新型氟[¹⁸F]标记的MAO-B分子探针的合成及其用于帕金森病发病机制的探索研究，2025-2027

4.    江苏省卫生健康委员会, 面上项目（M2022047）, 镓[⁶⁸Ga]标记的胰岛β细胞VMAT2显像药物的合成及生物学评价, 2023-2025

近五年代表性论文

[1]  Tang J, Liu C, Liu C, Hu Q, Fang Y, Chen Z. Evaluation of damage discrimination in dopaminergic neurons using dopamine transporter PET tracer [¹⁸F]FECNT-d₄. EJNMMI Research, 2024, 14: 78.  https://doi.org/10.1186/s13550-024-01140-3

[2]  Liu J, Kang J, Qi M, Tang J, Fang Y, Liu C, Hong J, Zuo J, Chen Z. Synthesis and initial evaluation of radioiodine-labelled deuterated tropane derivatives targeting dopamine transporter. Bioorganic & Medicinal Chemistry Letters, 2024, 102: 129678.  https://www.sciencedirect.com/science/article/pii/S0960894X24000805

[3]  Fang Y, Chen Z, Yang M. Small molecule probes for the specific imaging of monoamine oxidase A and monoamine oxidase B. iRADIOLOGY, 2024, 2: 191-215.  https://onlinelibrary.wiley.com/doi/abs/10.1002/ird3.70

[4]  Liu C, Fang Y, Tang J, Chen Z. Derivatization of dihydrotetrabenazine for technetium-99m labelling towards a radiotracer targeting vesicular monoamine transporter 2. Arabian Journal of Chemistry, 2023, 16: 104572.  https://www.sciencedirect.com/science/article/pii/S1878535223000333

[5]  Li Q, Hu Q, Tang J, Fang Y, Liu C, Liu J, Qi M, Chen Z, Zhang L. Deuterated [¹⁸F]fluoroethyl tropane analogs as dopamine transporter probes: Synthesis and biological evaluation. Nuclear Medicine and Biology, 2023, 118-119: 108334.  https://doi.org/10.1016/j.nucmedbio.2023.108334

[6]  Hu Q, Li Q, Tang J, Liu J, Fang Y, Liu C, Qi M, Chen Z. Synthesis and biological evaluation of ¹⁸F-labelled deuterated tropane derivatives as dopamine transporter probes. Arabian Journal of Chemistry, 2023, 16: 105278.  https://www.sciencedirect.com/science/article/pii/S1878535223007402

[7]  Fang Y, Liu C, Tang J, Pei Z, Chen Z. Visible-Light Photocatalytic Synthesis of Difluoromethylated Selenides from Selenosulfonates through a Radical Process. The Journal of Organic Chemistry, 2023, 88: 12658-12667.  https://doi.org/10.1021/acs.joc.3c01352

[8]  Ji L, Fang Y, Tang J, Liu C, Huang C, Hu Q, Li Q, Chen Z. Synthesis and biological evaluation of ¹⁸F-labelled dopamine D₃ receptor selective ligands. Bioorganic & Medicinal Chemistry Letters, 2022, 62: 128630.  https://doi.org/10.1016/j.bmcl.2022.128630

[9]  Huang C, Liu C, Tang J, Fang Y, Ji L, Hu Q, Li Q, Xie M, Chen Z. Development and validation of high-performance liquid chromatography method for analysis of β-CCT and its related substances. Arabian Journal of Chemistry, 2022, 15: 103725.  https://doi.org/10.1016/j.arabjc.2022.103725

[10]      Xu Y, Tang J, Liu C, Zhao C, Cao S, Yu H, Chen Z, Xie M. MicroPET imaging of vesicular monoamine transporter 2 revealed the potentiation of (+)-dihydrotetrabenazine on MPTP-induced degeneration of dopaminergic neurons. Nuclear Medicine and Biology, 2021, 96-97: 9-18.  https://www.ncbi.nlm.nih.gov/pubmed/33647803

[11]      Liu C, Tang J, Xu Y, Cao S, Fang Y, Zhao C, Chen Z. Molar activity of [¹⁸F]FP-(+)-DTBZ radiopharmaceutical: Determination and its effect on quantitative analysis of VMAT2 autoradiography. Journal of Pharmaceutical and Biomedical Analysis, 2021, 203: 114212.  https://www.ncbi.nlm.nih.gov/pubmed/34153939

[12]      Fang Y, Li X, Liu C, Tang J, Chen Z. Nucleophilic Substitution of Selenosulfonates with Me₃SiCF₂Br: Facile and Efficient Access to Bromodifluoromethylated Selenides under Metal-Free Conditions. The Journal of Organic Chemistry, 2021, 86: 18081-18093.  https://www.ncbi.nlm.nih.gov/pubmed/34823360

[13]      Cao S, Tang J, Liu C, Fang Y, Ji L, Xu Y, Chen Z. Synthesis and Biological Evaluation of [¹⁸F]FECNT-d₄ as a Novel PET Agent for Dopamine Transporter Imaging. Molecular Imaging and Biology, 2021, 23: 733-744.  https://www.ncbi.nlm.nih.gov/pubmed/33851345

[14]      Zhao C, Liu C, Tang J, Xu Y, Xie M, Chen Z. An Efficient Automated Radiosynthesis and Bioactivity Confirmation of VMAT2 Tracer [¹⁸F]FP-(+)-DTBZ. Molecular Imaging and Biology, 2020, 22: 265-273.  https://www.ncbi.nlm.nih.gov/pubmed/31165386

[15]      Tang J, Xu Y, Liu C, Fang Y, Cao S, Zhao C, Huang H, Zou M, Chen Z. PET imaging with [¹⁸F]FP-(+)-DTBZ in 6-OHDA-induced partial and full unilaterally -lesioned model rats of Parkinson's disease and the correlations to the biological data. Nuclear Medicine and Biology, 2020, 90-91: 1-9.  https://www.ncbi.nlm.nih.gov/pubmed/32861175