王欢,博士,教授,硕士生导师 |
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科学研究方向 |
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多肽化学生物学 |
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联系方式 |
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电 话:0516-83262137 |
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Email:wanghuan@nju.edu.cn |
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通 讯:江苏省徐州市云龙区铜山路209号,221004 |
个人简历
2005年本科毕业于北京大学,2010年博士毕业于美国马里兰大学,2010-2014年于美国伊利诺伊大学香槟分校进行博士后研究。2014年加入南京大学化学化工学院任职。国家入选海外高层次人才青年项目(2015),获国家自然科学基金委优秀青年基金(2019)、杰出青年基金资助(2023)。获中国化学会生命化学奖、英国皇家化学学会会士等荣誉。目前担任Org. Biomol. Chem.期刊的副主编。
承担科研课题
国家自然科学基金委员会, 青年科学基金项目(A类)[原国家杰出青年科学基金项目], 22325702, 环肽化学生物学, 2024-01-01 至 2028-12-31, 400万元, 在研, 主持
近五年代表性论文、专著
1. Chen Wang, Wangjian Sheng, et al and Chenyu Zhang*, Hongkai Bi* and Huan Wang*, siRNA-AGO2 complex inhibits bacterial gene translation: a promising therapeutic strategy for superbug infection, Cell Reports Medicine, 2025, DOI: 10.1016/j.xcrm.2025.101997
2. Yuqing Li, Yeying Ma, Yinzheng Xia, Tao Zhang, Shuaishuai Sun, Jiangtao Gao, * Hongwei Yao* and Huan Wang*, Discovery and biosynthesis of tricyclic copper-binding ribosomal peptides containing histidine-to-butyrine crosslinks, Nat. Commun. 2023, 14, 2944.
3. Shanqing Huang, Ying Wang, Chuangxu Cai, Xiuyun Xiao, Shulei Liu, Yeying Ma, Xiangqian Xie, Yong Liang, Hao Chen, Jiapeng Zhu, Julian D. Hegemann, * Hongwei Yao, * Wanqing Wei* and Huan Wang*, Discovery of a Unique Structural Motif in Lanthipeptide Synthetases for Substrate Binding and Interdomain Interactions, Angew. Chem. Int. Ed. 2022, 61, e202211382.
4. Lei Liu, Xinlong Fan, Boning Wang, Hong Deng, Tianhang Wang, Jie Zheng, Jun Chen, Zhuangzhi Shi* and Huan Wang*, P(III)-Directed Late-Stage Ligation and Macrocyclization of Peptides with Olefins by Rhodium Catalysis, Angew. Chem. Int. Ed. 2022, 61, e202206177.
5. Chang Zhao, Wangjian Sheng, Ying Wang, Jie Zheng, Xiangqian Xie, Yong Liang, Wanqing Wei,* Rui Bao* and Huan Wang*, Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases, Nat. Chem. Biol. 2022, 18, 724-732.
6. Yingying Zhang, Zhilai Hong, Liang Zhou, Zhenkun Zhang, Ting Tang, Erpeng Guo, Jie Zheng, Ciji Wang, Lei Dai, Tong Si* and Huan Wang*, Biosynthesis of Gut-Microbiota-Derived Lantibiotics Reveals a Subgroup of S8 Family Proteases for Class III Leader Removal, Angew. Chem. Int. Ed. 2022, 61, e202114414.