王政

个人简历

王政，博士，徐州医科大学药学院教授，博导，2018年在中国科学院苏州生物医学工程技术获得博士学位；2018-2020年获得日本学术振兴会（JSPS）资助，在日本川崎产业振兴研究所纳米医学创新中心Kazunori Kataoka 团队担任博士后研究员；2021-2024年通过中科院百人计划引进回国加入中国科学院苏州纳米技术与纳米仿生研究所。2025年通过徐州医科大学高层次人才引进计划，加入徐州医科大学药学院。入选江苏省双创人才、苏州市姑苏双创领军人才。

主要从事生物材料的开发以及癌症治疗、组织器官损伤修复等方面的研究。近年来以第一或通讯作者在 Science advances, Advanced Materials, Advanced Science, ACS Nano，Biomaterials 和Nano Today等国际权威期刊发表SCI论文32篇；申请中国发明专利9项，已授权7项；主持国自然科学青年基金、江苏省自然科学青年基金、苏州市基础研究试点项目等。

承担科研课题

1.      徐州医科大学高层次人才项目，生物活性材料在肿瘤免疫治疗的应用研究，2025年3月-2028年3月，100万，主持

2.      国家自然科学基金青年项目，兼具放疗定向驱动和放疗可控释药的仿生型纳米药物在胶质瘤放疗免疫联合治疗的应用研究，2023年1月-2025年12月，30万，主持

3.      江苏省自然科学基金青年项目，具有放疗定向驱动和放疗激活特性的纳米药物构建及其在胶质瘤放疗联合免疫治疗上的研究，2022年7月-2025年6月，20万，主持

4.      苏州市基础研究试点项目，仿生型纳米载药系统用于放疗激活的脑胶质瘤免疫治疗研究，2021年10月-2023年9月，45万,主持

5.      苏州市重大创新团队项目，心脏类器官构建技术及活体移植研究，2022年8月-2025年7月，1000万，子课题负责人

近五年代表性论文、专著

1.      Junna Lu, Yidan Zhang, Xin Zhao, Yu Ding, Fanshu Ma, Xiaochun Xie, Quanxin Ning, Hui Fang, Ziping Wu, Huayi Sun*, Fangman Chen*, Zheng Wang*，Co-delivery of CO/H2 gases for synergistic radiosensitization and intestinal protection in peritoneal metastases therapy. Biomaterials. 2026, 327, 123796 IF: 14.0

2.      Bingyuan Fei, Hui Wang, Yu Ding, Nannan Shao, Panyue Wen, Yanwei Cao, Junjie Li， Masaru Tanaka, Zheng Wang,* , Shuo Li,*，Reprogramming cellular senescence of hepatic stellate cells to combat liver fibrosis by targeted nanodrugs, Materials Today Bio, 2025, 33 101996

3.      Zheng Wang, Fangman Chen, Yi Cao, Fan Zhang, Lina Sun, Chao Yang, Xiaochun Xie, Ziping Wu, Madi Sun, Fanshu Ma, Dan Shao*, Kam W Leong*, Renjun Pei* . An Engineered Nanoplatform with Tropism Toward Irradiated Glioblastoma Augments Its Radioimmunotherapy Efficacy. Advanced Materials.2024, 36（32）, 2314197-2314197  IF: 29.4

4.      Zheng Wang#, Yinglu Chen#, Hui Fang, Kai Xiao, Ziping Wu, Xiaochun Xie, Jie Liu, Fangman Chen, Yi He, Liang Wang, Chao Yang*, Renjun Pei*, and Dan Shao*.Reprogramming Cellular Senescence in the Tumor Microenvironment Augments Cancer Immunotherapy Through Multifunctional Nanocrystal. Science Advances. 2024,10(44):7022-7034 IF: 12.5

5.      Shuting Zuo, Zhenyu Wang, Xiaoman Jiang, Yuewu Zhao, Panyue Wen, Jine Wang, Junjie Li, Masaru Tanaka, Shao Dan, Yan Zhang* and Zheng Wang*. Regulating tumor innervation by nanodrugs potentiates cancer immunochemotherapy and relieve chemotherapy-induced neuropathic pain. Biomaterials. 2024, 309, 122603 IF: 14.0

6.      Chao Yang, Yinglu Chen, Jie Liu, Wensheng Zhang, Yan He, Fangman Chen, Dan Shao*, Zheng Wang*, and Liang Wang*, Leveraging Senescent Cancer Cell Membrane to Potentiate Cancer Immunotherapy Through Biomimetic Nanovaccine. Advanced Science. 2024, 202400630. IF: 15.1

7.      Bingyuan Fei, Yuewu Zhao, Jine Wang, Panyue Wen, Junjie Li, Masaru Tanakad, Zheng Wang*, Shuo Li*, Leveraging Adrenergic Receptor Blockade for Enhanced Nonalcoholic Fatty Liver Disease Treatment via a Biomimetic Nanoplatform. Journal of Nanobiotechnology 2024, 22(1),591-606 IF: 10.0

8.      Wenqi Shen, Yecheng Li, Ziyi Yang, Wenjing Li, Yi Cao, Yilin Liu, Zheng Wang*, Renjun Pei* and Chungen Xing*, Tumor microenvironment reprogramming combined with immunogenic enhancement by nanoemulsions potentiates immunotherapy. Journal of Nanobiotechnology 2024. 22:154. IF: 10.0

9.      Junna Lu, Fangman Chen, Xiaochun Xie, Ziping Wu, Yinglu Chen, Yidan Zhang, Hui Fang, Feixia Ruan, Dan Shao*, Zheng Wang*, Renjun Pei*, X-ray-controllable release of carbon monoxide potentiates radiotherapy by ultrastable hybrid nanoreservoirs. Biomaterials 2023, 302，122313-122325

10.  Chao Yang, Yi He, Fangman Chen, Fan Zhang, Dan Shao, * and Zheng Wang*,Leveraging β-Adrenergic Receptor Signaling Blockade for Improved Cancer Immunotherapy Through Biomimetic Nanovaccine. Small（ISSN:1613-6810）.2023,19（14）， 2207029-2207040 IF: 13.3

11.  Chao Yang, Fan Zhang, Fangman Chen, Zhimin Chang, Yuewu Zhao, Dan Shao, Wen Sun*, Wen-fei Dong, and Zheng Wang*, Biomimetic Nanovaccines Potentiating Dendritic Cell Internalization via CXCR4-Mediated Macropinocytosis. Advanced Healthcare Materials. 2023, 12（5）, 2202064-2202076 IF: 10.0

12.  Lina Sun, Yi Cao, Wenjing Li, Li Wang, Pi Ding, Zhongzhong Lu, Fanshu Ma, Zheng Wang* and Renjun Pei*, Perovskite-Type Manganese Vanadate Sonosensitizers with Biodegradability for Enhanced Sonodynamic Therapy of Cancer Small 2023, 2300101. IF: 13.3

13.  Bingyuan Fei, Zhanhao Mo, Jinghui Yang, Zheng Wang* and Shuo Li*, Nanodrugs Reprogram Cancer-Associated Fibroblasts and Normalize Tumor Vasculatures for Sequentially Enhancing Photodynamic Therapy of Hepatocellular Carcinoma. International Journal of Nanomedicine, 2023, 18, 6379. IF = 8.0

14.  Lina Sun, Yi Cao, Zhongzhong Lua, Pi Ding, Zhili Wang, Fanshu Ma, Zheng Wang*, Renjun Pei*, A hypoxia-irrelevant Fe-doped multivalent manganese oxide sonosensitizer via a vacancy engineering strategy for enhanced sonodynamic therapy. Nano Today. 2022, 43, 101434-101444

15.  Wenqi Shen, Ping-an Yao, Wenjing Li, Changji Gu, Tian Gao, Yi Cao, Zheng Wang*, Renjun Pei*, Chungen Xing*, Cancer-associated fibroblast-targeted nanodrugs reshape colorectal tumor microenvironment to suppress tumor proliferation, metastasis and improve drug penetration. Journal of Materials Chemistry B, 2023, 11, 1871-1880. IF: 7.0

16.  16 Zhi-min Chang, Rui Zhang, Chao Yang*, Dan Shao, Yuguo Tang, Wen-fei Dong*, and Zheng Wang*, Cancer-Leukocyte Hybrid Membrane-Cloaked Magnetic Beads for Ultrasensitive Isolation, Purification and nondestructive Release of Circulating Tumor Cells. Nanoscale. 2020, 12, 19121. IF: 6.7

17.  Zhi-min Chang, Hang Zhou, Chao Yang, Rui Zhang, Qiannan You, Ruhong Yan, Li Li, Mingfeng Ge, Yuguo Tang, Wen-fei Dong, * and Zheng Wang*, Biomimetic Immunomagnetic Gold Hybrid Nanoparticles Coupled with Inductively Coupled Plasma Mass Spectrometry for the Detection of Circulating Tumor Cells. Journal of Materials Chemistry B. 2020, 8, 5019. IF: 7.0