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季 帅，副教授，博士，硕士生导师 药物分析教研室主任、党支部书记 |
科学研究方向 |
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天然活性成分的发现及功能研究 |
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联系方式 |
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电 话：0516-83262138 |
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Email：jishuai0115@xzhmu.edu.cn |
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通 讯：江苏省徐州市云龙区铜山路209号，221004 |
个人简历
江苏省“高层次创新创业人才引进计划”双创博士、江苏省高校“青蓝工程”优秀青年骨干教师。现担任中国植物学会药用植物及植物药专业委员会青年委员、中国民族医药学会信息与大数据分会理事、Frontiers in Pharmacology期刊副主编、Traditional Medicine Research期刊青年编委。主要从事天然活性成分的发现及功能研究，以第一/通讯作者发表SCI论文20余篇，主持国家级、省部级等多项科研课题。研究成果获教育部自然科学一等奖（第四）、江苏省教育教学与研究成果奖三等奖（第二）。
承担科研课题
1. 国家自然科学基金青年基金，81803382，基于功能化离子液体靶向富集的甘草中异戊烯基黄酮的制备分离及其诱导自噬构效关系研究，2019.01-2021.12，21万元，主持。
2. 江苏省自然科学基金面上项目，BK20221392，磁性聚离子液体配体垂钓方法的建立及其用于桑叶醇提物调控胰岛自噬的药效物质研究，2022.07-2025.06，10万元，主持。
3. 江苏省自然科学基金青年基金，BK20170253，基于功能化离子液体的甘草中抗肿瘤异戊烯基黄酮的特异性提取和萃取，2017.07-2020.06，20万元，主持。
4. 江苏省“高层次创新创业人才引进计划”双创博士项目，2017.07-2019.06，20万元，主持。
5. 徐州市重点研发计划，KC22079，基于离子液体提取的桑叶深加工新技术研究，2022.09-2024.08，25万元，主持。
近五年代表性论文
1. Xiaofei Chen, Ruili Ma, Weiguo Wu, Ran Gao, Yikang Shu, Mingxin Dong, Mengzhe Guo, Daoquan Tang, Danhua Li*, Shuai Ji*. Wighteone, a prenylated flavonoid from licorice, inhibits growth of SW480 colorectal cancer cells by allosteric inhibition of Akt. Journal of Ethnopharmacology 2024, 330: 118195.
2. Cuicui Zhu, Ziyu Wang, Ruili Ma, Weiguo Wu, Mingxin Dong, Xiaofei Chen, Yan Du, Daoquan Tang, Shuai Ji*. Selective enrichment of licorice triterpenoid saponins from complicated samples by magnetic poly(ionic liquid)-functionalized metal-organic framework. LWT - Food Science and Technology 2023, 185: 115143.
3. Lu Zhao, Xiaofei Chen, Xian Shao, Ziyu Wang, Yan Du, Cuicui Zhu, Wei Du, Daoquan Tang, Shuai Ji*. Prenylated phenolic compounds from licorice (Glycyrrhiza uralensis) and their anti-inflammatory activity against osteoarthritis. Food & Function 2022, 13: 795−805.
4. Xian Shao, Xiaofei Chen, Ziyu Wang, Cuicui Zhu, Yan Du, Daoquan Tang, Shuai Ji*. Diprenylated flavonoids from licorice induce death of SW480 colorectal cancer cells by promoting autophagy: Activities of lupalbigenin and 6,8-diprenylgenistein. Journal of Ethnopharmacology 2022, 296: 115488.
5. Shuai Ji*, Cuicui Zhu, Shikai Gao, Xian Shao, Xiaofei Chen, Hui Zhang, Daoquan Tang. Morus alba leaves ethanol extract protects pancreatic islet cells against dysfunction and death by inducing autophagy in type 2 diabetes. Phytomedicine 2021, 83: 153478.
6. Shuai Ji, Yujie Wang, Xian Shao, Cuicui Zhu, Yan Lin, Shikai Gao, Daoquan Tang. Extraction and purification of triterpenoid saponins from licorice by ionic liquid based extraction combined with in situ alkaline aqueous biphasic systems. Separation and Purification Technology 2020, 247: 116953.
7. Shuai Ji, Yujie Wang, Shikai Gao, Xian Shao, Wei Cui, Yan Du, Mengzhe Guo, Daoquan Tang. Highly efficient and selective extraction of minor bioactive natural products using pure ionic liquids: Application to prenylated flavonoids in licorice. Journal of Industrial and Engineering Chemistry 2019, 80: 352−360.
8. Shuai Ji, Dan-dan He, Zhen-yu Su, Yan Du, Yu-jie Wang, Shi-kai Gao, Meng-zhe Guo, Dao-quan Tang. P450 enzymes-based metabolic interactions between monarch drugs and the other constituent herbs: A strategy to explore compatibility mechanism of Sangju-Yin. Phytomedicine 2019, 58: 152866.
9. Shuai Ji, Xian Shao, Zhen-yu Su, Lei Ji, Yu-jie Wang, Yun-su Ma, Lu Zhao,Yan Du, Meng-zhe Guo, Dao-quan Tang. Segmented scan modes and polarity-based LC-MS for pharmacokinetic interaction study between Fufang Danshen Dripping Pill and Clopidogrel Bisulfate Tablet. Journal of Pharmaceutical and Biomedical Analysis 2019, 174: 367−375.
