封 亮

个人简历

学习工作经历

2018.6—至今，中国药科大学中药学院，中药制药系

2017.8—2018.2，美国 Cancer center/ Department of Pharmacology and Toxicology, Medical College of Wisconsin，合作导师：Dr. Ming You

2012.7—2018.4，江苏省中医药研究院，国家中医药管理局中药释药系统重点研究室

2009.9—2012.7，澳门科技大学中医药学院攻读中药学博士

2006.9—2009.7，江苏大学生药学专业理论课硕士学习，获医学硕士学位

2002.9—2006.7，江苏大学本科药学专业学习，获理学学士学位

获奖情况

江苏省第五期“333”工程第三层次中青年学术技术带头人、江苏省第十三批“六大人才高峰”高层次人才培养对象、江苏省青年医学重点人才、江苏省中医药十佳青年之星、江苏省双创企业博士、国家博士后基金获得者、江苏省政府留学奖学金获得者

学术兼职

世界中医药学会联合会中医药免疫专业委员会第一届理事会理事，世界中医药学会联合会中药网络药理学专业委员会第一届理事会理事，世界中医药学会联合会中药系统与工程专业委员会第一届理事会理事，世界中医药学会联合会中药上市后再评价专业委员会会员，中华中医药学会中药毒理学与安全性研究分会委员，江苏省中西医结合学会临床药学专业委员会青年委员，江苏省药理学会会员

承担科研课题

1.    国家自然科学基金面上项目，81973536，基于Sirt1/p38MAPK介导自噬探究牡丹皮萜苷组分干预“毒损肾络”作用与机制，2020.01-2023.12，主持。

2.    国家重大新药创制项目，2017ZX09301051，组分结构中药新品种奥斯替宝研发及其关键创新技术，2017.01-2020.12，主持。

3.    国家自然科学基金面上项目，81473394，基于病理网络多靶标的丹皮多组分防治糖尿病肾病的整合调节机制研究，2015.01-2018.12，主持。

4.    国家自然科学基金青年基金，81202906，基于非酶糖基化学说的生物色谱筛选丹皮防治糖尿病血管并发症的药效物质基础研究，2013.01-2015.12，主持。

5.    江苏省自然科学基金，BK2012491，基于细胞膜固相色谱筛选的丹皮防治糖尿病肾病的药效物质基础研究，2012.07-2015.07，主持。

6.    2013年江苏省高层次人才创新创业《蒲地蓝消炎口服液二次开发》济川药业集团有限公司，编号BRA2013144，子课题：蒲地蓝消炎口服液抗炎机理试验研究，2015.05-2017.05，主持。

7.    江苏省双创企业博士项目：小儿蒲地蓝糖浆研制，2016.06-2018.06，主持。

8.    江苏省青年医学重点人才项目，QNRC2016634，中药优效组分的发现策略和方法——以糖尿病相关疾病治疗方药为例，2017.01-2020.12，主持。

9.    神威药业（张家口）有限公司，校合2018-中18，经典名方《石决明散与槐花散》的开发研究，主持。

10.江西汇仁药业股份有限公司，肉苁蓉等中药材在肾宝片制剂原料中的化学物质组分研究，主持。

11.中医药现代化研究重点专项，2018YFC1706900，基于中药物料性质的(口服)剂型设计与制剂处方优化关键技术研究，984万，参与。

12.2015年国家公益性科研专项项目，201507004，与临床病证有关的确有疗效常用中药炮制技术与配伍减“毒”研究，2015.01-2017.12，参与。

13.国家中医临床研究基地业务建设第二批科研专项课题，JDZX2015K01，中医临床效方逆转肺癌靶向药物耐药的有效组分与机制，2015.12-2018.10，参与。

14.江苏省中医药领军人才项目，基于方药组分ADME/Tox特性的现代中药复方创新剂型设计，2006.01-2010.12，参与。

近五年代表性论文、专著

1.    Gu J, Feng L, Song J, Cui L, Liu D, Ma L, Jia X. The effect and mechanism of combination of total paeony glycosides and total ligustici phenolic acids against focal cerebral ischemia. Sci Rep. 2020 Feb 28;10(1):3689.

2.    Liang Feng*#, Zhi-yong Li#, Long Wang#, Xing-hua Li, Ya-ping Chen, Bing Yang, Dang Yang, Yuan-pei Lian, Xue-feng Hou, Jun-hui Li, Shu-min Ding and Xiao-bin Jia*. Wedelolactone-Loaded Micelles Ameliorate Doxorubicin-Induced Oxidative Injury in Podocytes by Improving Permeability and Bioavailability. Frontiers in Bioengineering and Biotechnology,2019; 7: 333.

3.    Zhu MM#, Wang L#, Yang D#, Li C, Pang ST, Li XH, Li R, Yang B, Lian YP, Ma L, Lv QL, Jia XB*, Feng L*. Wedelolactone alleviates doxorubicin-induced inflammation and oxidative stress damage of podocytes by IκK/IκB/NF-κB pathway. Biomed Pharmacother. 2019; 117:109088.

4.    Song J,Yang B, Jia XB, Li MY, Tan W, Ma ST, Shi XH, Feng L*. Distinctive Roles of Sirtuins on Diabetes, Protective or Detrimental? Front Endocrinol (Lausanne). 2018;9:724.

5.    Zhou Y, Zhang X, Li C, Yuan X, Han L, Li Z, Tan X, Song J, Wang G, Jia X, Feng L*, Qiao X, Liu J. Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9. Biomed Pharmacother. 2018; 106:434-442.

6.    Wang G, Dai G, Song J, Zhu M, Liu Y, Hou X, Ke Z, Zhou Y, Qiu H, Wang F, Jiang N, Jia X, Feng L. Lactone Component From Ligusticum chuanxiong Alleviates Myocardial Ischemia Injury Through Inhibiting Autophagy. Front Pharmacol. 2018; 9:301.

7.    Shumin Ding, Xuefeng Hou, Jie Song, Gang Wang, Xiaobin Tan, Ying Liu, Yuanli Zhou, Huihui Qiu, E Sun, Fujing Wang, Nan Jiang, Zihao Li, Jiping Liu, Liang Feng*, Xiaobin Jia. Regulation of Eclipta prostrata L. components on cigarette smoking-induced autophagy of bronchial epithelial cells via keap1-Nrf2 pathway. Envi tox. 2018 May 4. doi: 10.1002/tox.22567.

8.    Juan Chen, Minghua Zhang, Maomao Zhu, Liang Feng*, Xiaobin Jia*. Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1α/NF-κB signaling pathway. FOOD & FUNCTION. 2018;9(4):2386-2397.

9.    Liu Y, Jiang ZY, Zhou YL, Qiu HH, Wang G, Luo Y, Liu JB, Liu XW, Bu WQ, Song J, Cui L, Jia XB, Feng L.β-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway. Biomed Pharmacother. 2017; 93:490-497.

10.Feng L, Yang N, Li C, Tian G, Wang J, Dong ZB, Jia XB, Di LQ. Pudilan xiaoyan oral liquid alleviates LPS-induced respiratory injury through decreasing nitroxidative stress and blocking TLR4 activation along with NF-ΚB phosphorylation in mice. J Ethnopharmacol. 2018; 214:292-300.

11.Zhao Y, Wei J, Hou X, Liu H, Guo F, Zhou Y, Zhang Y, Qu Y, Gu J, Zhou Y, Jia X, Qin G*, Feng L*. SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy. Sci Rep. 2017;7(1):10285. 

12.Qiu HH#, Zhang L#, Zhu MM, Zhang MH, Chen J, Feng L*, Jia XB*, Jacob JA. Capture of anti-coagulant active ingredients from Moutan Cortex by platelet immobilized chromatography and evaluation of anticoagulant activity in rats. Biomed Pharmacother. 2017; 95:235-244. 

13.Chen J#, Yuan JR#, Zhou LQ#, Zhu MM, Shi ZQ, Song J, Xu QY, Yin GW, Lv Y, Luo Y, Jia XB*, Feng L*. Regulation of Different Components from Ophiopogon japonicus on Autophagy in Human Lung Adenocarcinoma A549 Cells through PI3K/Akt/mTOR Signaling Pathway. Biomedicine & Pharmacotherapy. 2017; 87:118-126.

14.Chen J#, Zhao D#, Zhu M#, Zhang M, Hou X, Ding W, Sun S, Bu W, Feng L*, Ma SP*, Jia X. Paeoniflorin ameliorates AGEs-induced mesangial cell injury through inhibiting RAGE/mTOR/autophagy pathway. Biomed Pharmacother. 2017; 89:1362-1369.

15.Yang N#, Dong ZB#, Tian G, Zhu MM, Li CC, Bu WQ, Chen J, Hou XF, Liu Y, Wang G, Jia XB, Di LQ, Feng L*. Protective effects of organic acid component from Taraxacum mongolicum Hand.-Mazz. against LPS-induced inflammation: Regulating the TLR4/IKK/NF-κB signal pathway. Journal of Ethnopharmacology. 2016,194(395-402).

16.Gu JF#, Chen J#, Yang N，Hou XF, Wang J, Tan XB, Feng L*, Jia XB*. Combination of Ligusticum chuanxiong and Radix Paeoniae ameliorats focal cerebral ischemic in MCAO rats via endoplasmic reticulum stress-dependent apoptotic signaling pathway. Journal of Ethnopharmacology. 2016,187(313-24).

17.Chen J#, Hou XF#, Wang G, Zhong QX, Liu Y, Qiu HH, Yang N, Gu JF, Wang CF, Zhang L, Song J, Huang LQ, Jia XB*, Zhang MH*, Feng L*. Terpene glycoside component from Moutan Cortex ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-related inflammatory responses.Journal of Ethnopharmacology. 2016;193(433-44).

18.Wang CF#, Yuan JR#, Qin D#, Gu JF, Zhao BJ, Zhang L, Zhao D, Chen J, Hou XF, Yang N, Bu WQ, Wang J, Li C, Tian G, Dong ZB, Feng L*, Jia XB*. Protection of tauroursodeoxycholic acid on high glucose-induced human retinal microvascular endothelial cells dysfunction and streptozotocin-induced diabetic retinopathy rats. Journal of Ethnopharmacol. 2016; 185:162-70.

19.Yang N#, Li C#, Tian G, Zhu MM, Bu WQ, Chen J, Hou XF, Di LQ, Jia XB*, Dong ZB*, Feng L*. Organic acid component from Taraxacum mongolicum Hand.-Mazz alleviates inflammatory injury in lipopolysaccharide-induced acute tracheobronchitis of ICR mice through TLR4/NF-κB signaling pathway. International Immunopharmacology, 2016,34:92-100.

20. Zhao BJ#, Wang J#, Song J, Wang CF, Gu JF, Yuan JR, Zhang L, Jiang J, Feng L*, Jia XB*. Beneficial Effects of a Flavonoid Fraction of Herba Epimedii on Bone Metabolism in Ovariectomized Rats. Planta Medica. 2016;82(4):322-9.