刘宏丽

个人简历

2020年6月毕业于兰州大学药物化学生物学专业，获得理学博士学位。2020年8月至今在徐州医科大学药学院药物化学教研室从事教学与科研工作。主持国家自然科学基金青年科学基金1项、校优秀人才启动基金1项、江苏省高校面上项目1项等科研项目。在Br J Pharmacol、ACS Chem Neurosci、Phytochemistry、Phys Chem Chem Phys、Int J Mol Sci等期刊发表研究论文十余篇。目前主要从事与肾脏疾病相关靶标的药物设计和发现研究。

承担科研课题

1. 国家自然科学基金青年基金，22107090，具有动力学选择性的c-Src抑制剂的设计、合成及其对多囊肾抑制剂活性研究，2022.01-2024.12，30万，主持。

2. 徐州医科大学优秀人才启动基金，D2020036，磷酸化对Tau蛋白错误折叠和聚集机制的研究，2020.09-2023.08，20万，主持。

近五年代表性论文

1. Liu Hongli, Zhang Haoran, IJzerman Adriaan P, Guo Dong*. The translational value of ligand-receptor binding kinetics in drug discovery. British Journal of Pharmacology. 2023, doi:10.1111/bph.16241. (IF:7.3)

2. Chen Mohan, Li Zheng, Sun Gang, Jin Shuang, Hao Xiyue, Zhang Chi, Liu Ling, Zhang Ling, Liu Hongli*, Xue Yunsheng*. Theoretical study on the free radical scavenging potency and mechanism of natural coumestans: Roles of substituent noncovalent interaction and solvent. Phytochemistry. 2023, 207:113580. (IF:3.8)

3. Liu Hongli, Li Qin, Xiong Chunmei, Zhong Haiyang, Zhang Qianqian, Liu Huanxiang*, Yao Xiaojun. Uncovering the effect of pS202/pT205/pS208 triple phosphorylations on the conformational features of the key fragment G192-T212 of tau protein. ACS Chemical Neuroscience, 2021, 12(6):1039-1048. (IF:4.418)

4. Liu Hongli, Zhong Haiyang, Xu Zerong, Zhang Qianqian, Shah Syed Jawad Ali, Liu Huanxiang*, Yao Xiaojun. The misfolding mechanism of the key fragment R3 of tau protein: a combined molecular dynamics simulation and markov state model study. Physical Chemistry Chemical Physics, 2020, 22(19):10968-10980. (IF:3.676)

5. Liu Hongli, Liu Xuewei, Zhou Shuangyan, An Xiaoli, Liu Huanxiang*, Yao Xiaojun. Disclosing the template-induced misfolding mechanism of tau protein by studying the dissociation of the boundary chain from the formed tau fibril based on a steered molecular dynamics simulation. ACS Chemical Neuroscience, 2019, 10(3):1854-1865. (IF:4.486)