姜力群

个人简历

男，现任徐州医科大学、江苏省新药与临床药学重点实验室副教授，中国药学会制药工程委员会青年委员，徐州市生态健康协会理事。长期从事吸入及镇痛类药物新剂型、功能食品的研究和开发。先后参与863计划、国家重大新药创制项目等国家及省部级项目近10项，主持国家自然科学基金项目等项目5项。承接企事业单位委托研发项目近10项，完成药品、消毒产品以特医食品等近10项产品的开发。发表论文30余篇，其中SCI论文10余篇，授权专利11项。

承担科研课题

1.    国家自然科学基金, 81502995，基于FRET效应对壳聚糖纳米载体生物清除动力学和机制的研究，2016.01-2018.12，17.9万，主持     .

2.    国家自然科学基金, 81773643，一种光/酶双重敏感的“特洛伊木马”式肿瘤靶向递药系统的构建与评价, 2018-2019, 22万， 参与.

3.    中国博士后基金, 针对烈性病毒性呼吸道传染病的多功能干粉吸入递药系统的开发,     2020 -2022, 18万，主持.

4.    江苏省博士后基金, 用于烈性病毒性呼吸道传染病的抗病毒药物干粉吸入递送系统的制备及评价, 2020 -2022, 4万，主持.

5.    徐州科技计划项目, 壳聚糖纳米载体对Kupffer细胞极化分型的调节机制及在肝缺血再灌注损伤治疗中的应用, 2019 -2021, 4万，主持.

6.    江苏省药学会靳培英项目, 基于完整皮肤结构的人工皮肤膜的建立及在利/丙双卡因透皮制剂优化中的应用, 2023-2026, 9万，主持.

7.    校企合作课题, L001喷雾剂处方工艺的研发, 2020-2021, 15 万，主持.

8.    校企合作课题, A-001干粉吸入递药系统的开发的生物学试验, 2020-2022, 14万，主持.

9.    校企合作课题, 萘敏维滴眼剂制备技术优化研究, 2022-2022, 5万，主持.

10. 校企合作课题, 制霉素阴道栓、红霉素软膏、 双唑泰栓制备技术优化研究, 2022-2023,      15万，主持.

11. 校企合作课题, 用于PEDF基因递送的脂质载体的构建及产业化应用, 2023-2025, 20万，      主持.

近五年代表性论文、专著

1.      Li Huiyang#, Liu Shuo#, Dai Wenjin, Yao Bingmei, Zhou Yong, Si Sujia, Yu Hairong, Zhao Riguang, Jin Fang, Jiang Liqun*. Pressure-sensitive multivesicular liposomes as a smart drug-delivery system for high-altitude pulmonary edema. J Control Release. 2024, 365:301-316. (IF:10.8)

2.      Xu Ya, Li Huiyang, Sun Nan, Yao Bingmei, Dai Wenjin, Wang Jian, Si Sujia, Liu Shuo, Jiang Liqun*. Dry Powder Formulations for Inhalation Require a Smaller Aerodynamic Diameter for Usage at High Altitude. J Pharm Sci. 2023, 112(10):2655-2666. (IF:3.8)

3.      Jiang Liqun #, Wang Yun, Wei Xiangrong, Yang Ling, Liu Shuo, Wang Yan, Xu Ya, Wang Ziyao, Zhang Cong, Zhang Mi, Zhang Yudong, Jin Fang, Yin Xiaoxing *. Improvement in phenotype homeostasis of macrophages by chitosan nanoparticles and subsequent impacts on liver injury and tumor treatment. Carbohyd Polym, 2022, 277:118891. (IF: 11.2)

4.      Jiang Liqun #, Zhang Mi, Bai Yuting, Cui Feiyan, Zhang Cong, Wang Ziyao, Si Sujia, Yang Ling, Wang Yun, Zhang Yudong, Li Lei, Liu Shuo, Wei Xiangrong, Wang Yan, Xu Ya, Meng Jian*. O-carboxymethyl chitosan based pH/hypoxia-responsive micelles relieve hypoxia and induce ROS in tumor microenvironment. Carbohyd Polym, 2022, 275:118611. (IF: 11.2)

5.      Zhang Mi, Si Sujia, Dai Wenjin, Yang Jian, Wang Yan, Wei Xiangrong, Liu Shuo, Xu Chengyi, Zhang Cong, Jin Fang*, Jiang Liqun*. A large particle size is required by a nano/micron sized-fluticasone propionate inhalable suspension for asthma treatment. Colloids Surf B Biointerfaces. 2023, 228:113364. (IF:5.8)

6.      Jiang Liqun#,*, Wang Ziyao, Wang Yan, Liu Shuo, Xu Ya, Zhang Cong, Li Lei, Si Sujia, Yao Bingmei, Dai Wenjin, Li Huiyang. Re-exposure of chitosan by an inhalable microsphere providing the re-education of TAMs for lung cancer treatment with assistant from sustained H2S generation. Int J Pharm. 2023, 25;642:123142. (IF:5.8)

7.      Meng Jian, Li Lei, Xu Ya, Wei Xiangrong, Chen Du, Chen Congliang, Liu Shuo, Wang Ziyao, Shi Guangwei, Wang Shoupeng, Zhou Xiaokai, Jiang Liqun*. A simple liposome-based bionic bacterium for tumor treatment by re-education of tumor-associated microphages in combination with chemotherapy. Colloids Surf B Biointerfaces. 2023, 22:113069. (IF:5.8)

8.      Qin Xichun, Zhou Yeqing, Wang Yuzhuo, Wang Ziyao, Wang Yun, Chen Jiali, Zhu Lidong, Quan Xiaoyu, Liu Zhiwei, Zhang Hao, Jiang Liqun*, Dong Hongyan*, Zhang Zhongming*. Preparation and Characterization of protein-loaded PFC nanoemulsions for the treatment of heart diseases by pulmonary administration. Eur J Pharm Sci, 2021, 158:105690. (IF: 4.6)

9.      Jiang Liqun#,*, Wang Tingyu, Wang Yun, Wang Ziyao, Bai Yuting. Co-disposition of chitosan nanoparticles by multitypes of hepatic cells and their subsequent biological elimination: the mechanism and kinetic studies at the cellular and animal levels. Int J Nanomed, 2019:14 6035–6060. (IF: 8.0)

10.  Jiang Liqun#, Wang Tingyu, Webster Thomas J, Duan Huajian, Qiu Jingying, Zhao Ziming, Yin Xiaoxing*, Zheng Chunli*. Intracellular disposition of chitosan nanoparticles in macrophages: intracellular uptake, exocytosis, and intercellular transport. Int J Nanomed, 2017, 12: 6383~6398. (IF: 8.0)

11.  11）Jiang Liqun#,*, Duan Huajian, Ji Xiangxiang, Wang Tingyu, Wang Yun, Qiu Jingying. Application of a simple desolvation method to increase the formation yield, physical stability and hydrophobic drug encapsulation capacity of chitosan-based nanoparticles. Int J Pharm, 2018, 545(1-2):117~127. (IF: 5.8)